| Breast cancer in the elderly: a histological assessment. | |
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MedLine Citation:
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PMID: 19817895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To understand the correlation between the expression status of different biological markers in breast cancers in the elderly. METHODS AND RESULTS: Three hundred and ninety-seven cases were evaluated for expression of hormone receptors [oestrogen receptors (ER) alpha and beta, progesterone receptor (PR)], basal markers [p63, cytokeratin (CK) 5/6 and CK14] and others (HER2/neu, synaptophysin and chromogranin). The expression rates were 60, 29, 25, 6, 14, 8, 28, 17 and 5%, respectively, for these markers. The expression of ER alpha and beta, PR, synaptophysin and chromogranin at any level correlated with low nuclear or tumour grades, whereas the expression of HER2/neu, CK5/6 and CK14 at any level correlated with high nuclear grade. By using hierarchical clustering, groups of HER2, luminal and basal types were identified. In addition, a neuroendocrine group was also identified, being characterized by expression of synaptophysin, chromogranin, ER and PR, but not HER2/neu, and other basal cytokeratins. This group was associated with lower nuclear grade, and hence better prognosis. CONCLUSIONS: Breast cancer in the elderly shows similar molecular groupings as other breast cancers, with an additional neuroendocrine group that is associated with a favourable biological marker profile. |
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Authors:
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Gary M Tse; Puay-Hoon Tan; Kin-Mang Lau; Victor Piana de Andrade; Philip C W Lui; Joaquim S Vong; Benjaporn Chaiwun; Christopher C Lam; Alex M Yu; Takuya Moriya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histopathology Volume: 55 ISSN: 1365-2559 ISO Abbreviation: Histopathology Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-12 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 441-51 Citation Subset: IM |
Affiliation:
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Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Ngan Shing Street, Shatin, Hong Kong. garytse@cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / metabolism* Breast Neoplasms / metabolism*, pathology* Chromogranin A / metabolism Cohort Studies Estrogen Receptor alpha / metabolism Estrogen Receptor beta / metabolism Female Humans Keratin-14 / metabolism Keratin-5 / metabolism Keratin-6 / metabolism Membrane Proteins / metabolism Receptor, erbB-2 / metabolism Receptors, Progesterone / metabolism Synaptophysin / metabolism Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/CKAP4 protein, human; 0/Chromogranin A; 0/Estrogen Receptor alpha; 0/Estrogen Receptor beta; 0/HER2 protein, human; 0/Keratin-14; 0/Keratin-5; 0/Keratin-6; 0/Membrane Proteins; 0/Receptors, Progesterone; 0/Synaptophysin; 0/Tumor Markers, Biological; EC 2.7.10.1/Receptor, erbB-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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