Document Detail

Breast cancer and human immunodeficiency virus infection: issues for the 21st century.
MedLine Citation:
PMID:  12804353     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: As we enter the 21st century, AIDS and breast cancer are two pressing issues in women's health. The spread of AIDS continues unabated. More than 21.8 million people have died of AIDS, and it is estimated that as of December 2000 an additional 36.1 million people, mostly in sub-Saharan Africa, were infected with the human immunodeficiency virus. In addition, women now constitute almost one half of all AIDS cases. With the widespread use of highly active antiretroviral therapy in the United States, the overall health and survival of HIV(+) individuals has improved dramatically. Thus, as the HIV(+) population matures, we will be called on to diagnose and treat more cases of breast cancer in seropositive women. What can we expect as the incidence of these two diseases begins to overlap? METHODS: Medline search, and review of the relevant literature. RESULTS: Forty-six published cases of breast cancer in HIV(+) individuals identified. CONCLUSIONS: Based on epidemiologic data from Western countries and Africa, HIV infection is not permissive for breast cancer. This is reflected in the paucity of available data. Early reports consisted of case reports, describing advanced cancers with unusual presentations and uniformly poor prognoses. Recent series describe more favorable prognoses and long-term survivors. It appears that hormonal therapy is well tolerated and effective, even in cases of locally advanced disease, and the toxicity from standard chemotherapy regimens is unacceptably high.
Amber A Guth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  12     ISSN:  1540-9996     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-13     Completed Date:  2003-08-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Department of Surgery, New York University School of Medicine, New York, New York, USA.
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MeSH Terms
Africa / epidemiology
Antineoplastic Agents / therapeutic use
Breast Neoplasms / complications*,  epidemiology,  therapy*
Chemotherapy, Adjuvant
HIV Seropositivity / complications*,  epidemiology
Radiotherapy, Adjuvant
Risk Factors
Survival Rate
United States / epidemiology
Women's Health*
World Health
Reg. No./Substance:
0/Antineoplastic Agents

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