Document Detail


Breast cancer and active and passive smoking: the role of the N-acetyltransferase 2 genotype.
MedLine Citation:
PMID:  10933269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association of breast cancer with passive and active smoking was investigated in slow and fast acetylators of aromatic amines in a Geneva, Switzerland, study in 1996-1997. A slow acetylator was homozygous for one, or heterozygous for two, of three N-acetyltransferase 2 (NAT2) polymorphisms determined on buccal cell DNA from 177 breast cancer cases and 170 age-matched, population controls. The reference group consisted of women never regularly exposed to active or passive smoke. Among premenopausal women, the odds ratios were homogeneous in slow and fast acetylators: 3.2 (95% confidence interval (CI): 1.2, 8.7) for passive smoking and 2.9 (95% CI: 1.1, 7.5) for active smoking. Among postmenopausal women, the odds ratios for fast acetylators were 11.6 (95% CI: 2.2, 62.2) for passive and 8.2 (95% CI: 1.4, 46.0) for active smoking; the corresponding effects were also apparent but less strong in slow acetylators. After the nonexposed and the passive smokers were grouped in a single reference category, active smoking was associated with postmenopausal breast cancer in slow acetylators (odds ratio (OR) = 2.5, 95% CI: 1.0, 6.2) but not in fast acetylators (OR = 1.3, 95% CI: 0.5, 3.3). Thus, the associations of both passive and active smoking with breast cancer appear stronger in fast than in slow NAT2 genotypes. Separating passive smokers from the nonexposed impacts on the inference about a possible NAT2-smoking interaction.
Authors:
A Morabia; M S Bernstein; I Bouchardy; J Kurtz; M A Morris
Related Documents :
8643789 - Does smoking really kill anybody?
19953089 - Differences in genetic background between active smokers, passive smokers, and non-smok...
22606369 - Sources and determinants of vitamin d intake in danish pregnant women.
9016739 - Behavioural impairment in smoke environments.
20015449 - Toxicity of smoke extracts towards a549 lung cells: role of acrolein and suppression by...
20818519 - The health risk assessment of organochlorine pesticides in smoked fish products availab...
6862739 - Women alcoholics--are they different from other women?
14716179 - Treatment of menopause-associated vasomotor symptoms: position statement of the north a...
18173799 - Relationship between campylobacter rectus and periodontal status during pregnancy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  152     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-08-17     Completed Date:  2000-08-17     Revised Date:  2010-09-08    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  226-32     Citation Subset:  IM    
Affiliation:
Division of Clinical Epidemiology, University Hospital, Geneva, Switzerland. alfredo.morabio@hcuge.ch
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylation
Adult
Aged
Arylamine N-Acetyltransferase / genetics*
Body Mass Index
Breast Neoplasms / etiology*,  genetics
Case-Control Studies
Educational Status
Female
Genotype
Humans
Middle Aged
Postmenopause / metabolism
Premenopause / metabolism
Risk Factors
Smoking / adverse effects*
Switzerland
Tobacco Smoke Pollution / adverse effects*
Chemical
Reg. No./Substance:
0/Tobacco Smoke Pollution; EC 2.3.1.5/Arylamine N-Acetyltransferase; EC 2.3.1.5/NAT2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of continuing or stopping smoking during pregnancy on infant birth weight, crown-heel length,...
Next Document:  Risk of ovarian cancer in relation to estrogen and progestin dose and use characteristics of oral co...