| Breast Cancer Subtype and Distant Recurrence after Ipsilateral Breast Tumor Recurrence. | |
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MedLine Citation:
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PMID: 23292516 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: There is little information about the impact of breast cancer subtype on prognosis after ipsilateral breast tumor recurrence (IBTR). METHODS: One hundred eighty-five patients were classified according to breast cancer subtype, as approximated by estrogen receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67, of IBTR, and we evaluated whether breast cancer subtype was associated with distant recurrence after IBTR. RESULTS: There was a significant difference in distant disease-free survival (DDFS) after IBTR according to breast cancer subtype defined by a cutoff of the Ki-67 index of 20 % (p = 0.0074, log-rank test). The 5-year DDFS rates for patients with luminal A, luminal B, triple-negative, and HER2 types were 86.3, 57.1, 56.6, and 65.9 %, respectively. In addition, breast cancer subtype was significantly associated with distant recurrence after IBTR on adjustment for various clinicopathologic factors (p = 0.0027, Cox proportional hazards model). CONCLUSIONS: Our study suggests that breast cancer subtype based on immunohistochemical staining predicts the outcomes of patients with IBTR. Further analyses are needed (UMIN-CTR number UMIN000008136). |
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Authors:
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Makoto Ishitobi; Yasuhiro Okumura; Nobuyuki Arima; Atsushi Yoshida; Katsuhiko Nakatsukasa; Takuji Iwase; Tadahiko Shien; Norikazu Masuda; Satoru Tanaka; Masahiko Tanabe; Takehiro Tanaka; Yoshifumi Komoike; Tetsuya Taguchi; Reiki Nishimura; Hideo Inaji |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-6 |
Journal Detail:
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Title: Annals of surgical oncology Volume: - ISSN: 1534-4681 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, isitobi-ma@mc.pref.osaka.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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