Document Detail

Breakpoint zone of bcr in chronic myelogenous leukemia does not correlate with disease phase or prognosis.
MedLine Citation:
PMID:  3203293     Owner:  NLM     Status:  MEDLINE    
The presence of a zone 4 rearrangement in the bcr of two chronic myelogenous leukemia (CML) cell lines and 25 CML patients was investigated by hybridization of HindIII-EcoRI double-digested DNA with the homologous HindIII-BglII breakpoint cluster region (bcr) probe. A rearrangement in zone 4 was found in the EM2 cell line and in 11 of the 25 patients. The presence of a zone 4 rearrangement was not associated with phase of disease, clinical evidence of acceleration, or pathologic evidence of acceleration. The difference between the actuarial duration of chronic phase for patients without (33 months) and with (22 months) a zone 4 rearrangement was not significant. A breakpoint in zone 4 of the bcr in patients with CML does not appear to be a determinant of prognosis.
D Przepiorka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  36     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-02-02     Completed Date:  1989-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Pittsburgh Cancer Institute, Pennsylvania.
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MeSH Terms
Blotting, Southern
Chromosome Aberrations*
Chromosomes, Human, Pair 22
Deoxyribonuclease EcoRI
Deoxyribonuclease HindIII
Gene Rearrangement*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*,  mortality
Nucleic Acid Hybridization
Restriction Mapping
Reg. No./Substance:
EC 3.1.21.-/Deoxyribonuclease EcoRI; EC 3.1.21.-/Deoxyribonuclease HindIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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