Document Detail


Breakpoint clusters of the PML gene in acute promyelocytic leukemia: primary structure of the reciprocal products of the PML-RARA gene in a patient with t(15;17).
MedLine Citation:
PMID:  7682097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DNA studies of the translocation t(15;17) in acute promyelocytic leukemia (APL) have shown that the retinoic acid receptor alpha (RARA) gene on chromosome 17 is juxtaposed to the promyelocytic leukemia (PML) gene on chromosome 15. The PML breakpoints have been mapped to 3 clusters: bcr1, bcr2, and bcr3. We have examined the PML breakpoint distribution in a series of 33 Chinese patients with APL. Twenty-two patients fell within bcr1, 2 within bcr2, and 9 within bcr3. The primary structure of the reciprocal chromosome translocation joints of one patient and that of their normal counterparts have been determined and compared to those of 2 previously reported cases. These studies revealed possible topoisomerase II cleavage sites close to the breakpoints and suggested implications of DNA attachment sites to nuclear matrix. We propose that these features are relevant to the process of illegitimate recombination generating the translocation.
Authors:
S Dong; J P Geng; J H Tong; Y Wu; J R Cai; G L Sun; S R Chen; Z Y Wang; C J Larsen; R Berger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  6     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-07     Completed Date:  1993-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Biology, Shanghai Rui-Jin Hospital, Shanghai Second Medical University, China.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/L11593;  L11594;  L24529;  S57791;  S57794;  S57796;  S57797;  X69763;  Z15047;  Z15048
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Carrier Proteins / genetics*
Chromosomes, Human, Pair 15 / ultrastructure*
Chromosomes, Human, Pair 17 / ultrastructure*
Consensus Sequence
DNA Mutational Analysis
DNA Topoisomerases, Type II / genetics
Gene Rearrangement*
Genes*
Humans
Introns
Leukemia, Promyelocytic, Acute / genetics*
Molecular Sequence Data
Neoplasm Proteins / genetics
Receptors, Retinoic Acid
Recombinant Fusion Proteins / genetics
Sequence Homology, Nucleic Acid
Transcription Factors / genetics
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Neoplasm Proteins; 0/Receptors, Retinoic Acid; 0/Recombinant Fusion Proteins; 0/Transcription Factors; EC 5.99.1.3/DNA Topoisomerases, Type II

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