Document Detail

Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration.
MedLine Citation:
PMID:  19404334     Owner:  NLM     Status:  MEDLINE    
Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.
Dorothea Godt; Ulrich Tepass
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Publication Detail:
Type:  News    
Journal Detail:
Title:  Nature cell biology     Volume:  11     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-06-02     Revised Date:  2012-06-01    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  536-8     Citation Subset:  IM    
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MeSH Terms
CCAAT-Enhancer-Binding Proteins / metabolism
Cell Movement / physiology*
Drosophila Proteins / metabolism,  physiology*
Drosophila melanogaster
Ecdysone / metabolism
Gene Expression Regulation / physiology
Janus Kinases / metabolism
Models, Biological
Nuclear Proteins / physiology*
Oogenesis / physiology*
Ovarian Follicle / cytology*,  physiology
Protein Binding / physiology
Receptors, Steroid / metabolism
STAT Transcription Factors / metabolism
Signal Transduction / physiology*
Transcription Factors / metabolism
Reg. No./Substance:
0/CCAAT-Enhancer-Binding Proteins; 0/Drosophila Proteins; 0/Nuclear Proteins; 0/Receptors, Steroid; 0/STAT Transcription Factors; 0/Transcription Factors; 0/abrupt protein, Drosophila; 0/ecdysone receptor; 0/taiman protein, Drosophila; 148997-45-9/slbo protein, Drosophila; 3604-87-3/Ecdysone; EC Kinases; EC protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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