| Breaking biological barriers with a toothbrush. | |
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MedLine Citation:
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PMID: 17652208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toothbrushing exposes epithelia and other tissues of the oral cavity to mechanical stress. Here, we investigated whether brushing induces cell wounding--plasma membrane disruption--in epithelial and other cell types in the oral cavity. Brushing of the gingivae and tongues of rats resulted in a striking increase in the number of cells positive for a marker of disruption injury. These cells included those in all strata of the gingival epithelium, and in the skeletal muscle of the tongue. Additionally, we found that brushing resulted in an increase in c-fos expression by junctional epithelial and skeletal muscle cells. Epithelial barrier function, however, was not overtly affected by brushing, despite the observed individual injuries to cells. We concluded that brushing disrupts cell plasma membrane barriers in the oral cavity and activates gene expression events that may lead to local adaptive changes in tissue architecture beneficial to gingival health. |
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Authors:
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K Amano; K Miyake; J L Borke; P L McNeil |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of dental research Volume: 86 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-26 Completed Date: 2007-08-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 769-74 Citation Subset: D; IM |
Affiliation:
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Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912-2000, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / pathology Epithelial Attachment / cytology, injuries*, metabolism Epithelial Cells / metabolism, pathology Gene Expression Gingiva / cytology, injuries* Male Microscopy, Confocal Muscle Fibers, Skeletal / metabolism, pathology Proto-Oncogene Proteins c-fos / biosynthesis Rats Rats, Sprague-Dawley Tongue / cytology, injuries* Toothbrushing / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-fos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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