Document Detail


Breaking the barrier in stroke: what should we know? A mini-review.
MedLine Citation:
PMID:  22574976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The blood-brain barrier (BBB) has been considered as an important regulator of brain homeostasis, and its disturbance has been implicated in the onset and/or evolution of many pathological manifestations of neurodegenerative and inflammatory diseases [1, 2]. In particular, BBB breakdown has been closely associated with the primary insult, as well as the secondary cell death of stroke. Here, we review the pioneering contributions of leading scientists who have vested interest in advancing our understanding of the pivotal role of BBB in stroke, but also exploiting this knowledge in developing novel BBB-based therapeutic regimens to abrogate stroke symptoms. The study of BBB as a fundamental research theme and as a target for clinical applications in stroke can be approached in three main themes namely, basic science research, translational and clinical research, and emerging therapies for BBB repair in stroke. This minireview captures cutting-edge discoveries establishing BBB as a central target for abetting neuroprotection and neurorestoration in stroke.
Authors:
Cesar V Borlongan; Antonio A Rodrigues; Maria Carolina Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  18     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-12-26     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3615-23     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612 USA. cborlong@health.usf.edu
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MeSH Terms
Descriptor/Qualifier:
Blood-Brain Barrier*
Humans
Stroke / physiopathology*
Translational Medical Research
Grant Support
ID/Acronym/Agency:
R01 NS071956/NS/NINDS NIH HHS; R01 NS071956-01/NS/NINDS NIH HHS
Comments/Corrections

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