Document Detail

Breaking the 10(-7) barrier for RI measurements in nanoliter volumes.
MedLine Citation:
PMID:  12403605     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Refractive index (RI) detection is a common technique used in chemical and biochemical analysis. It can be employed to perform universal solute detection in microHPLC and CE, as well as temperature measurements. However, accurate RI measurements in nanoliter volumes still present a significant challenge. Here we present an alternative method to extract RI information encoded in spatial distribution of the backscattered fringes produced by a microinterferometric backscatter detector (MIBD) based on spatial Fourier analysis. By monitoring the phase in the Fourier domain, we were able to obtain detection limits of 7 x 10(-8) RIU. It was also shown that such calculations could be performed in real time, thus making MIBD with Fourier analysis compatible with microHPLC, CE, and FIA.
Dmitry Markov; Deepak Begari; Darryl J Bornhop
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Analytical chemistry     Volume:  74     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-29     Completed Date:  2002-12-03     Revised Date:  2003-11-03    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5438-41     Citation Subset:  -    
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