| Breakfast cereals and risk of type 2 diabetes in the Physicians' Health Study I. | |
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MedLine Citation:
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PMID: 18198313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the association between breakfast cereal consumption and the risk of type 2 diabetes (DM). RESEARCH METHODS AND PROCEDURES: We analyzed prospectively data from 21,152 male participants of the Physicians' Health Study I. Consumption of breakfast cereals was estimated using an abbreviated food questionnaire, and incident DM was ascertained through yearly follow-up questionnaires. RESULTS: The average age was 53.6 +/- 9.4 years (range, 39.7 to 85.9) during the initial assessment of cereal intake (1981 to 1983). During a mean follow-up of 19.1 years, 1958 cases of DM occurred. The crude incidence rates of DM were 57.7, 53.8, 43.5, and 35.4 cases/10,000 person-years for people reporting breakfast cereal intake of 0, <or=1, 2 to 6, and >or=7 servings/wk, respectively. In a Cox regression model adjusting for age, cigarette smoking, BMI, physical activity, vegetable consumption, and alcohol intake, hazard ratios (95% confidence interval) for DM were 1.0 (reference), 0.89 (0.79 to 1.00), 0.76 (0.67 to 0.86), and 0.63 (0.55 to 0.72) from the lowest to the highest category of cereal consumption, respectively (p for trend < 0.0001). In secondary analyses, the inverse association between cereal intake and DM was stronger with whole-grain than refined cereals. DISCUSSION: These results suggest that intake of breakfast cereals might confer a lower risk of DM. Consumption of whole-grain products may help lower the risk of DM. |
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Authors:
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Jinesh Kochar; Luc Djoussé; J Michael Gaziano |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 15 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-01-16 Completed Date: 2008-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 3039-44 Citation Subset: IM |
Affiliation:
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Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston MA 02120, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cereals / metabolism* Diabetes Mellitus, Type 2 / epidemiology* Follow-Up Studies Health Surveys Humans Incidence Male Middle Aged Proportional Hazards Models Prospective Studies Risk Factors United States |
| Grant Support | |
ID/Acronym/Agency:
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CA-34944/CA/NCI NIH HHS; CA-40360/CA/NCI NIH HHS; HL-26490/HL/NHLBI NIH HHS; HL-34595/HL/NHLBI NIH HHS; K01 HL-70444/HL/NHLBI NIH HHS |
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