Document Detail


Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness.
MedLine Citation:
PMID:  20885292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery of consciousness. RESULTS: Propofol-induced decrease in consciousness linearly correlates with decreased corticocortical and thalamocortical connectivity in frontoparietal networks (i.e., default- and executive-control networks). Furthermore, during propofol-induced unconsciousness, a negative correlation was identified between thalamic and cortical activity in these networks. Finally, negative correlations between default network and lateral frontoparietal cortices activity, present during wakefulness, decreased proportionally to propofol-induced loss of consciousness. In contrast, connectivity was globally preserved in low-level sensory cortices, (i.e., in auditory and visual networks across sedation stages). This was paired with preserved thalamocortical connectivity in these networks. Rather, waning of consciousness was associated with a loss of cross-modal interactions between visual and auditory networks. CONCLUSIONS: Our results shed light on the functional significance of spontaneous brain activity fluctuations observed in functional magnetic resonance imaging. They suggest that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. They emphasize the importance of thalamocortical connectivity in higher-order cognitive brain networks in the genesis of conscious perception.
Authors:
Pierre Boveroux; Audrey Vanhaudenhuyse; Marie-Aurélie Bruno; Quentin Noirhomme; Séverine Lauwick; André Luxen; Christian Degueldre; Alain Plenevaux; Caroline Schnakers; Christophe Phillips; Jean-François Brichant; Vincent Bonhomme; Pierre Maquet; Michael D Greicius; Steven Laureys; Mélanie Boly
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  113     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2010-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1038-53     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia and Intensive Care Medicine, University of Liège, Liège, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Conscious Sedation / methods
Consciousness / drug effects*,  physiology*
Deep Sedation / methods
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Nerve Net / drug effects,  physiology*
Propofol / pharmacology*
Rest / physiology*
Unconsciousness / chemically induced,  physiopathology
Young Adult
Chemical
Reg. No./Substance:
2078-54-8/Propofol
Comments/Corrections
Comment In:
Anesthesiology. 2010 Nov;113(5):1007-9   [PMID:  20881591 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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