| Breakdown of mucosal immunity in gut by 2,3,7,8-tetraclorodibenzo-p-dioxin (TCDD). | |
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MedLine Citation:
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PMID: 21432354 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: Mucosal immunity plays a pivotal role for body defense against infection and allergy. The aim of this study was to clarify the effects of 2,3,7,8-tetraclorodibenzo-p-dioxin (TCDD) on mucosal immunity in the gut. METHODS: Fecal IgA level and oral tolerance induction were examined in TCDD-treated mice. Flow cytometric and histological analyses were also performed. RESULTS: Single oral administration of low dose 2,3,7,8-TCDD resulted in a marked decrease in IgA secretion in the gut without any effects on the cellular components of gut-associated lymphoid tissues (GALT) including Peyer's patches (PPs) and mesenteric lymph nodes (LNs). Decressed IgA secretion by TCDD was not observed in aryl hydrocarbon receptor (AhR)-deficient mice. Flow cytometric analysis revealed that IgA B cells in PPs and the mesenteric LNs remained unchanged in the TCDD-treated mice. An immunofluorescence study also demonstrated that a significant number of cytoplasmic IgA cells were present in the lamina propria of the gut in the TCDD-treated mice. Furthermore, oral tolerance induction by ovalbumin (OVA) was impaired in the TCDD-treated mice and OVA-specific T cell proliferation occurred in the peripheral lymphoid tissues including the spleen and LNs. CONCLUSIONS: These results suggest that a relatively low dose of TCDD impairs mucosal immunity in the gut and induces systemic sensitization by oral antigens. |
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Authors:
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Hirokazu Kinoshita; Jun Abe; Kenji Akadegawa; Hideaki Yurino; Tetsuya Uchida; Shigaku Ikeda; Kouji Matsushima; Sho Ishikawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental health and preventive medicine Volume: 11 ISSN: 1342-078X ISO Abbreviation: Environ Health Prev Med Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2011-03-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609642 Medline TA: Environ Health Prev Med Country: Japan |
Other Details:
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Languages: eng Pagination: 256-63 Citation Subset: - |
Affiliation:
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Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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