Document Detail

Breakdown in the brain network subserving moral judgment in criminal psychopathy.
MedLine Citation:
PMID:  22037688     Owner:  NLM     Status:  MEDLINE    
Neuroimaging research has demonstrated the involvement of a well-defined brain network in the mediation of moral judgment in normal population, and has suggested the inappropriate network use in criminal psychopathy. We used functional magnetic resonance imaging (fMRI) to prove that alterations in the brain network subserving moral judgment in criminal psychopaths are not limited to the inadequate network use during moral judgment, but that a primary network breakdown would exist with dysfunctional alterations outside moral dilemma situations. A total of 22 criminal psychopathic men and 22 control subjects were assessed and fMRI maps were generated to identify (i) brain response to moral dilemmas, (ii) task-induced deactivation of the network during a conventional cognitive task and (iii) the strength of functional connectivity within the network during resting-state. The obtained functional brain maps indeed confirmed that the network subserving moral judgment is underactive in psychopathic individuals during moral dilemma situations, but the data also provided evidence of a baseline network alteration outside moral contexts with a functional disconnection between emotional and cognitive elements that jointly construct moral judgment. The finding may have significant social implications if considering psychopathic behavior to be a result of a primary breakdown in basic brain systems.
Jesus Pujol; Iolanda Batalla; Oren Contreras-Rodríguez; Ben J Harrison; Vanessa Pera; Rosa Hernández-Ribas; Eva Real; Laura Bosa; Carles Soriano-Mas; Joan Deus; Marina López-Solà; Josep Pifarré; José M Menchón; Narcís Cardoner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-27
Journal Detail:
Title:  Social cognitive and affective neuroscience     Volume:  7     ISSN:  1749-5024     ISO Abbreviation:  Soc Cogn Affect Neurosci     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-22     Completed Date:  2013-05-07     Revised Date:  2013-12-10    
Medline Journal Info:
Nlm Unique ID:  101288795     Medline TA:  Soc Cogn Affect Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  917-23     Citation Subset:  IM    
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MeSH Terms
Brain / blood supply,  physiology*
Brain Mapping*
Case-Control Studies
Criminals / psychology*
Image Processing, Computer-Assisted
Judgment / physiology*
Magnetic Resonance Imaging
Neuropsychological Tests
Oxygen / blood
Statistics as Topic
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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