Document Detail

Brattleboro rats have deficient adrenocorticotropin responses to activation of central alpha 1-adrenoceptors.
MedLine Citation:
PMID:  2174337     Owner:  NLM     Status:  MEDLINE    
This experiment was designed to test further the hypothesis that vasopressin is the major mediator of the ACTH response to activation of central alpha 1-adrenoceptors in the rat. The alpha 1-adrenergic agonist methoxamine was given intracerebro-ventricularly to conscious vasopressin-deficient (homozygous Brattleboro) and normal rats bearing venous and intracerebro-ventricular cannulae. Methoxamine stimulated the secretion of ACTH in the normal, but not in the vasopressin-deficient, rats. The data confirm that vasopressin, rather than CRH-41 or oxytocin, is the major hypothalamic peptide that mediates the effects of central alpha 1-adrenoceptors on the pituitary corticotrophs.
S al-Damluji; A White; M Besser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinology     Volume:  127     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-17     Completed Date:  1991-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2849-53     Citation Subset:  AIM; IM    
Department of Endocrinology, Medical College of St. Bartholomew's Hospital, London, United Kingdom.
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MeSH Terms
Adrenocorticotropic Hormone / blood,  secretion*
Cerebral Ventricles / drug effects,  physiology*
Drinking Behavior
Injections, Intraventricular
Methoxamine / administration & dosage,  pharmacology*
Models, Neurological
Neurons / physiology
Rats, Brattleboro
Receptors, Adrenergic, alpha / drug effects,  physiology*
Reference Values
Species Specificity
Vasopressins / deficiency,  physiology
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 11000-17-2/Vasopressins; 390-28-3/Methoxamine; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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