Document Detail


Brassinosteroids regulate organ boundary formation in the shoot apical meristem of Arabidopsis.
MedLine Citation:
PMID:  23213257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spatiotemporal control of the formation of organ primordia and organ boundaries from the stem cell niche in the shoot apical meristem (SAM) determines the patterning and architecture of plants, but the underlying signaling mechanisms remain poorly understood. Here we show that brassinosteroids (BRs) play a key role in organ boundary formation by repressing organ boundary identity genes. BR-hypersensitive mutants display organ-fusion phenotypes, whereas BR-insensitive mutants show enhanced organ boundaries. The BR-activated transcription factor BZR1 directly represses the cup-shaped cotyledon (CUC) family of organ boundary identity genes. In WT plants, BZR1 accumulates at high levels in the nuclei of central meristem and organ primordia but at a low level in organ boundary cells to allow CUC gene expression. Activation of BR signaling represses CUC gene expression and causes organ fusion phenotypes. This study uncovers a role for BR in the spatiotemporal control of organ boundary formation and morphogenesis in the SAM.
Authors:
Joshua M Gendron; Jiang-Shu Liu; Min Fan; Ming-Yi Bai; Stephan Wenkel; Patricia S Springer; M Kathryn Barton; Zhi-Yong Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-04
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-28     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21152-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / genetics*,  metabolism
Arabidopsis Proteins / metabolism
Brassinosteroids / metabolism*
Cell Nucleus / metabolism
Chromatin Immunoprecipitation
Gene Expression Regulation, Plant*
Genes, Plant
Meristem / physiology*
Microscopy, Confocal / methods
Microscopy, Electron, Scanning / methods
Mutation
Phenotype
Plant Shoots / metabolism
Signal Transduction
Grant Support
ID/Acronym/Agency:
R01 GM066258/GM/NIGMS NIH HHS; R01 GM066258/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Brassinosteroids
Comments/Corrections
Comment In:
Trends Plant Sci. 2013 May;18(5):235-6   [PMID:  23384602 ]
Curr Biol. 2013 Feb 18;23(4):R152-4   [PMID:  23428325 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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