| Brassinosteroids regulate organ boundary formation in the shoot apical meristem of Arabidopsis. | |
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MedLine Citation:
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PMID: 23213257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spatiotemporal control of the formation of organ primordia and organ boundaries from the stem cell niche in the shoot apical meristem (SAM) determines the patterning and architecture of plants, but the underlying signaling mechanisms remain poorly understood. Here we show that brassinosteroids (BRs) play a key role in organ boundary formation by repressing organ boundary identity genes. BR-hypersensitive mutants display organ-fusion phenotypes, whereas BR-insensitive mutants show enhanced organ boundaries. The BR-activated transcription factor BZR1 directly represses the cup-shaped cotyledon (CUC) family of organ boundary identity genes. In WT plants, BZR1 accumulates at high levels in the nuclei of central meristem and organ primordia but at a low level in organ boundary cells to allow CUC gene expression. Activation of BR signaling represses CUC gene expression and causes organ fusion phenotypes. This study uncovers a role for BR in the spatiotemporal control of organ boundary formation and morphogenesis in the SAM. |
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Authors:
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Joshua M Gendron; Jiang-Shu Liu; Min Fan; Ming-Yi Bai; Stephan Wenkel; Patricia S Springer; M Kathryn Barton; Zhi-Yong Wang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-12-04 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-19 Completed Date: 2013-02-28 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 21152-7 Citation Subset: IM |
Affiliation:
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Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arabidopsis
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genetics*,
metabolism Arabidopsis Proteins / metabolism Brassinosteroids / metabolism* Cell Nucleus / metabolism Chromatin Immunoprecipitation Gene Expression Regulation, Plant* Genes, Plant Meristem / physiology* Microscopy, Confocal / methods Microscopy, Electron, Scanning / methods Mutation Phenotype Plant Shoots / metabolism Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM066258/GM/NIGMS NIH HHS; R01 GM066258/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arabidopsis Proteins; 0/Brassinosteroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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