Document Detail

The Brandes-Friesen case reports: how should we interpret the news?
MedLine Citation:
PMID:  7641155     Owner:  NLM     Status:  MEDLINE    
In this issue (see pages 561 to 566 two case reports by Lorne J. Brandes and Linda A. Friesen illustrate a temporal relation between the discontinuation or initiation of therapy with certain non-antineoplastic agents (lithium, carbamazepine and an H1-antihistamine) and the clinical course of cancer. Only an accumulation of similar case reports and the results of epidemiologic and controlled clinical studies will show whether the temporal relation observed in these cases is also a causal one. In the absence of strong, let alone conclusive, evidence that antidepressants or antihistamines promote the growth of tumours in human beings, a recommendation to stop using these medications would be premature. The news about these case reports and about animal studies on the tumour-promoting potential of some antidepressants and antihistamines is likely to spread through the media. The realistic and responsible option for physicians and clinical investigators is to help patients and prospective participants in clinical trials to interpret this information in a balanced and reasonable fashion.
D J Roy; N MacDonald
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  153     ISSN:  0820-3946     ISO Abbreviation:  CMAJ     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  569-71     Citation Subset:  AIM; IM    
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MeSH Terms
Carbamazepine / therapeutic use*
Cell Division / drug effects
Histamine H1 Antagonists / therapeutic use*
Lithium / therapeutic use*
Neoplasms / pathology*
Remission, Spontaneous
Reg. No./Substance:
0/Histamine H1 Antagonists; 298-46-4/Carbamazepine; 7439-93-2/Lithium
Comment On:
CMAJ. 1995 Sep 1;153(5):561-6   [PMID:  7641154 ]
Comment In:
CMAJ. 1996 Jan 1;154(1):16-7   [PMID:  8542562 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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