Document Detail


Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.
MedLine Citation:
PMID:  23412370     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.
Authors:
Wenyu Zhang; David I Bryson; Jason B Crumpton; Jessica Wynn; Webster L Santos
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-23     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  2436-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Boronic Acids / chemistry*
HIV-1 / genetics,  metabolism
Humans
Peptide Library
Peptides / chemistry*,  metabolism
Protein Binding
RNA, Viral / metabolism*
Grant Support
ID/Acronym/Agency:
R01 GM093834/GM/NIGMS NIH HHS; R01 GM093834/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Boronic Acids; 0/Peptide Library; 0/Peptides; 0/RNA, Viral
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bovine xenograft locking Puddu plate versus tricalcium phosphate spacer non-locking Puddu plate in o...
Next Document:  Time Trends in Patient Characteristics Treated on Acute Stroke-Units: Results From the Austrian Stro...