| Branched chain amino acids as adjunctive therapy to ketogenic diet in epilepsy: pilot study and hypothesis. | |
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MedLine Citation:
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PMID: 19687389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pilot prospective follow-up study of the role of the branched chain amino acids as additional therapy to the ketogenic diet was carried out in 17 children, aged between 2 and 7 years, with refractory epilepsy. All of these patients were on the ketogenic diet; none of them was seizure free, while only 13 had more or less benefited from the diet. The addition of branched chain amino acids induced a 100% seizure reduction in 3 patients, while a 50% to 90% reduction was noticed in 5. Moreover, in all of the patients, no reduction in ketosis was recorded despite the change in the fat-to-protein ratio from 4:1 to 2.5:1. Although our data are preliminary, we suggest that branched chain amino acids may increase the effectiveness of the ketogenic diet and the diet could be more easily tolerated by the patients because of the change in the ratio of fat to protein. |
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Authors:
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Athanasios Evangeliou; Martha Spilioti; Vai Doulioglou; Panagiota Kalaidopoulou; Anestis Ilias; Astrinia Skarpalezou; Irini Katsanika; Serafia Kalamitsou; Konstantina Vasilaki; Ilias Chatziioanidis; Kiriakos Garganis; Evangelos Pavlou; Sotirios Varlamis; Nikolaos Nikolaidis |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-08-17 |
Journal Detail:
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Title: Journal of child neurology Volume: 24 ISSN: 1708-8283 ISO Abbreviation: J. Child Neurol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-06 Completed Date: 2010-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1268-72 Citation Subset: IM |
Affiliation:
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4th Paediatric Clinic, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece. aeevange@auth.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Branched-Chain
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adverse effects,
therapeutic use* Anticonvulsants / therapeutic use Child Child, Preschool Epilepsy / diet therapy*, drug therapy, urine Follow-Up Studies Humans Ketogenic Diet* Ketosis / urine Models, Biological Pilot Projects Prospective Studies Seizures / diet therapy, drug therapy, urine Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Branched-Chain; 0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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