Document Detail


Branched-chain amino acid therapy for spinocerebellar degeneration: a pilot clinical crossover trial.
MedLine Citation:
PMID:  10397076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The potential effects of branched-chain amino acids (BCAAs) on spinocerebellar degeneration (SCD) were explored in eleven patients. METHODS: The patients received 200 ml of BCAA-rich solution, 2 mg of thyrotropin-releasing hormone (TRH; protirelin), or a placebo daily for 7 days each in a random order. An SCD score was used to quantify the severity of symptoms. PATIENTS: Eleven patients with SCD (7 male, 4 female; mean age 60+/-11; mean disease duration 5.5 years) participated in this study. RESULTS: The mean SCD score of the eleven patients improved significantly by the BCAA treatment compared with the baseline. The conditions of five of the eleven patients (45%) were clearly improved by the BCAA treatment. All of the responders manifested predominantly cerebellar symptoms, but no prominent parkinsonian symptoms. Two patients with marked rigidity and akinesia did not respond to the treatment. CONCLUSION: We concluded that BCAAs do have a beneficial effect on functional improvement in patients with SCD, and that further large scale studies are needed.
Authors:
N Mori; Y Adachi; T Takeshima; Y Kashiwaya; A Okada; K Nakashima
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  38     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-09     Completed Date:  1999-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
Affiliation:
Division of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine, Yonago.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amino Acids, Branched-Chain / therapeutic use*
Cross-Over Studies
Female
Humans
Male
Middle Aged
Pilot Projects
Severity of Illness Index
Single-Blind Method
Spinocerebellar Degenerations / drug therapy*,  physiopathology
Thyrotropin-Releasing Hormone / therapeutic use
Treatment Outcome
Chemical
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 24305-27-9/Thyrotropin-Releasing Hormone

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