Document Detail

Branched-chain amino acid supplementation and the immune response of long-distance athletes.
MedLine Citation:
PMID:  11985939     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Intense long-duration exercise has been associated with immunosuppression, which affects natural killer cells, lymphokine-activated killer cells, and lymphocytes. The mechanisms involved, however, are not fully determined and seem to be multifactorial, including endocrine changes and alteration of plasma glutamine concentration. Therefore, we evaluated the effect of branched-chain amino acid supplementation on the immune response of triathletes and long-distance runners. METHODS: Peripheral blood was collected prior to and immediately after an Olympic Triathlon or a 30k run. Lymphocyte proliferation, cytokine production by cultured cells, and plasma glutamine were measured. RESULTS: After the exercise bout, athletes from the placebo group presented a decreased plasma glutamine concentration that was abolished by branched-chain amino acid supplementation and an increased proliferative response in their peripheral blood mononuclear cells. Those cells also produced, after exercise, less tumor necrosis factor, interleukins-1 and -4, and interferon and 48% more interleukin-2. Supplementation stimulated the production of interleukin-2 and interferon after exercise and a more pronounced decrease in the production of interleukin-4, indicating a diversion toward a Th1 type immune response. CONCLUSIONS: Our results indicate that branched-chain amino acid (BCAA) supplementation recovers the ability of peripheral blood mononuclear cells proliferate in response to mitogens after a long distance intense exercise, as well as plasma glutamine concentration. The amino acids also modify the pattern of cytokine production leading to a diversion of the immune response toward a Th1 type of immune response.
Reinaldo A Bassit; Letícia A Sawada; Reury F P Bacurau; Franciso Navarro; Eivor Martins; Ronaldo V T Santos; Erico C Caperuto; Patrícia Rogeri; Luís F B P Costa Rosa
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  18     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-02     Completed Date:  2002-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-9     Citation Subset:  IM    
Department of Histology and Embryology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Amino Acids, Branched-Chain / administration & dosage*,  blood
Bicycling / physiology
Cytokines / blood
Dietary Supplements*
Glutamine / blood
Immune System / drug effects*,  physiology
Immunity, Cellular / drug effects,  physiology
Lymphocyte Activation / drug effects
Physical Endurance / drug effects,  physiology*
Running / physiology
Swimming / physiology
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Cytokines; 56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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