Document Detail


Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?
MedLine Citation:
PMID:  21502372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabolic remodelling is an integral part of the pathogenesis of heart failure. Although much progress has been made in our current understanding of the metabolic impairment involving carbohydrates and fatty acids in failing hearts, relatively little is known about the changes and potential impact of amino acid metabolism in the onset of heart diseases. Although most amino acid catabolic activities are found in the liver, branched-chain amino acid (BCAA) catabolism requires activity in several non-hepatic tissues, including cardiac muscle, diaphragm, brain and kidney. In this review, the new insights into the regulation of cardiac BCAA catabolism and functional impact on cardiac development and physiology will be discussed along with the potential contribution of impairment in BCAA catabolism to heart diseases. A particular focus will be the new information obtained from recently developed genetic models with BCAA catabolic defects and metabolomic studies in human and animal models. These studies have revealed the potential role of BCAA catabolism in cardiac pathophysiology and have helped to distinguish BCAA metabolic defects as an under-appreciated culprit in cardiac diseases rather than an epiphenomenon associated with metabolic remodelling in the failing heart.
Authors:
Ying Huang; Meiyi Zhou; Haipeng Sun; Yibin Wang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cardiovascular research     Volume:  90     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-08-17     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-3     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids, Branched-Chain / metabolism*
Animals
Energy Metabolism / physiology*
Heart Failure / metabolism*
Humans
Phosphoprotein Phosphatases / metabolism*
Ventricular Remodeling / physiology*
Grant Support
ID/Acronym/Agency:
HL080111/HL/NHLBI NIH HHS; HL088640/HL/NHLBI NIH HHS; HL098954/HL/NHLBI NIH HHS; HL103205/HL/NHLBI NIH HHS; HL70079/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids, Branched-Chain; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.16/protein phosphatase 2C
Comments/Corrections

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