Document Detail


Brainy but not too brainy: starting and stopping neuroblast divisions in Drosophila.
MedLine Citation:
PMID:  15626494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drosophila neuroblasts are similar to mammalian neural stem cells in that they self-renew and have the potential to generate many different types of neurons and glia. They have already proved useful for uncovering asymmetric division components and now look set to provide insights into how stem cell divisions are initiated and terminated during neural development. In particular, some of the humoral factors and short-range 'niche' signals that modulate neuroblast activity during postembryonic development have been identified. In addition, recent studies have begun to reveal how the total number of cells generated by a single neuroblast is regulated by spatial and temporal cues from Hox proteins and a transcription-factor series linked to cell cycle progression.
Authors:
Cédric Maurange; Alex P Gould
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in neurosciences     Volume:  28     ISSN:  0166-2236     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-31     Completed Date:  2005-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  30-6     Citation Subset:  IM    
Affiliation:
Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology,  embryology,  growth & development
Cell Differentiation / physiology*
Cell Division / physiology*
Drosophila / cytology*,  embryology,  physiology
Gene Expression Regulation, Developmental
Nerve Tissue Proteins / metabolism
Neurons / cytology*
Stem Cells / cytology,  physiology*
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins

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