|Brainstem volumetric alterations in children with autism.|
|PMID: 18812009 Owner: NLM Status: MEDLINE|
|BACKGROUND: Although several studies have examined brainstem volume in autism, results have been mixed and no investigation has specifically measured gray- and white-matter structures. The aim of this investigation was to assess gray- and white-matter volumes in children with autism.
METHOD: Subjects included 22 right-handed, non-mentally retarded boys with autism and 22 gender- and age-matched controls. Magnetic resonance imaging (MRI) scans were obtained using a 1.5-T scanner and volumetric measurements were performed using the BRAINS2 software package. Gray- and white-matter volumes were measured using a semi-automated segmentation process.
RESULTS: There were no significant differences in age and total brain volume (TBV) between the two groups but full-scale IQ was higher in controls. A decrease in brainstem gray-matter volume was observed in the autism group before and after controlling for TBV. No significant differences were observed in white-matter volume. A significant relationship was observed between brainstem gray-matter volume and oral sensory sensitivity as measured by the Sensory Profile Questionnaire (SPQ).
CONCLUSIONS: Findings from this study are suggestive of brainstem abnormalities in autism involving gray-matter structures with evidence supporting the existence of a relationship between these alterations and sensory deficits. These results are consistent with previous investigations and support the existence of disturbances in brainstem circuitry thought to be implicated in the sensory dysfunction observed in autism.
|R J Jou; N J Minshew; N M Melhem; M S Keshavan; A Y Hardan|
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|Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-09-24|
|Title: Psychological medicine Volume: 39 ISSN: 1469-8978 ISO Abbreviation: Psychol Med Publication Date: 2009 Aug|
|Created Date: 2009-07-02 Completed Date: 2009-09-28 Revised Date: 2014-09-08|
Medline Journal Info:
|Nlm Unique ID: 1254142 Medline TA: Psychol Med Country: England|
|Languages: eng Pagination: 1347-54 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Brain Stem / pathology*
Child Development Disorders, Pervasive / diagnosis, pathology*, psychology
Dominance, Cerebral / physiology
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging*
Nerve Fibers, Myelinated / pathology
Nerve Net / pathology, physiopathology
Statistics as Topic
|K23 MH064027/MH/NIMH NIH HHS; K23 MH064027-06/MH/NIMH NIH HHS; MH 64027/MH/NIMH NIH HHS; P50 HD055748/HD/NICHD NIH HHS|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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