Document Detail

Brainstem maturation after antenatal steroids exposure in premature infants as evaluated by auditory brainstem-evoked response.
MedLine Citation:
PMID:  12774139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Antenatal steroids result in fetal lung maturation, but may retard brain development. Auditory brainstem-evoked response (ABR) is a noninvasive assessment of brainstem maturation. The objective of this study was to determine if antenatal steroids affect brainstem maturation in infants </=32 weeks gestational age (GA). DESIGN/METHODS: Bilateral monaural ABR were performed within the first 24 hours using 80 db nHL unfiltered click stimuli at a repetition rate of 39.9/seconds. ABR waveforms were categorized into Response Types based on response replicability and peak identification. Absolute wave latencies and interpeak latencies were measured when applicable. Data were collected for antenatal steroid exposure, mode of delivery, chorioamnionitis in utero, exposure to illicit drugs, exposure to magnesium sulfate, mechanical ventilation and 5 minute Apgar score <5 minute. Infants with TORCH infections, unstable conditions, and chromosomal disorders were excluded. RESULTS: Of 186 infants studied, 130 received antenatal steroids. Data were analyzed in 2 week GA intervals. There was a significant difference (P<0.05) in race (29 vs 39% African-American), birth weight (1231 vs 1416 gm) and use of magnesium sulfate (60 vs 32%) among infants who did and did not receive antenatal steroids, respectively. There was no significant difference in the other parameters measured. Even after controlling for confounding variables, there was no difference between absolute wave latencies or interpeak latencies between groups at either 28 to 29 weeks' or 30 to 31 weeks' postmenstrual age. There was no significant difference in frequency distribution of ABR waveform Response Types between groups. CONCLUSIONS: Antenatal steroids have neither a deleterious nor beneficial effect on brainstem maturation as measured by ABR in infants at </=32 weeks GA.
Sanjiv B Amin; Mark S Orlando; Larry E Dalzell; Kathleen S Merle; Ronnie Guillet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  23     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-29     Completed Date:  2003-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, Strong Children's Hospital, USA.
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MeSH Terms
Betamethasone / pharmacology*
Brain Stem / drug effects*,  embryology*,  physiopathology
Evoked Potentials, Auditory, Brain Stem / drug effects*,  physiology*
Fetal Organ Maturity / drug effects,  physiology
Gestational Age
Glucocorticoids / pharmacology*
Infant, Newborn
Infant, Premature*
Lung / drug effects*,  embryology*,  physiopathology
Prenatal Care*
Reaction Time / drug effects,  physiology
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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