| Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 19539726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Symptomatic ischemia following aneurysmal subarachnoid hemorrhage (SAH) is common but poorly understood and inadequately treated. Severe constriction of the major arteries at the base of the brain, termed vasospasm, traditionally has been thought to be a proximal event underlying these ischemias, although microvascular changes also have been described. The vast majority of studies aimed at understanding the pathogenesis of ischemic deficits, and vasospasm have focused on the interaction of the "spasmogen" of the extravasated blood with the smooth muscle and endothelium of the arteries. This has led to a comparative neglect of the contribution of the CNS to the maintenance of cerebral perfusion. In the present study, we focused on the role of the rostral ventromedial medulla (RVM) in modulating cerebral perfusion at rest and following an experimental SAH in the rat. Changes in cerebral blood flow (CBF) were measured using laser-Doppler flowmetry and three-dimensional optical microangiography. Focal application of a GABA(A) receptor agonist and antagonist was used to respectively inactivate and activate the RVM. We show here that the RVM modulates cerebral blood flow under resting conditions, and further, contributes to restoration of cerebral perfusion following a high-grade SAH. Failure of this brainstem compensatory mechanism could be significant for acute perfusion deficits seen in patients following subarachnoid hemorrhage. |
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Authors:
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J S Cetas; D R Lee; N J Alkayed; R Wang; J J Iliff; M M Heinricher |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-06-17 |
Journal Detail:
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Title: Neuroscience Volume: 163 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-04 Completed Date: 2009-12-14 Revised Date: 2011-10-18 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 719-29 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239-3098, USA. cetasj@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bicuculline / pharmacology Cerebral Angiography Cerebrovascular Circulation / drug effects, physiology* GABA Agonists / pharmacology GABA Antagonists / pharmacology GABA-A Receptor Agonists GABA-A Receptor Antagonists Imaging, Three-Dimensional Laser-Doppler Flowmetry Male Medulla Oblongata / blood supply*, drug effects, physiopathology* Middle Cerebral Artery / drug effects, physiopathology Muscimol / pharmacology Rats Rats, Sprague-Dawley Rest / physiology Subarachnoid Hemorrhage / drug therapy, physiopathology* Vasospasm, Intracranial / chemically induced, drug therapy, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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HL093140/HL/NHLBI NIH HHS; NS044313/NS/NINDS NIH HHS; NS052364/NS/NINDS NIH HHS; R01 HL093140-01/HL/NHLBI NIH HHS; R01 HL093140-02/HL/NHLBI NIH HHS; R01 HL093140-05/HL/NHLBI NIH HHS; R01 NS044313-09/NS/NINDS NIH HHS; R01 NS052364-02/NS/NINDS NIH HHS; R01 NS052364-03/NS/NINDS NIH HHS; R01 NS052364-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/GABA Agonists; 0/GABA Antagonists; 0/GABA-A Receptor Agonists; 0/GABA-A Receptor Antagonists; 2763-96-4/Muscimol; 485-49-4/Bicuculline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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