Document Detail

Brainstem auditory evoked responses in 200 patients with multiple sclerosis.
MedLine Citation:
PMID:  7369720     Owner:  NLM     Status:  MEDLINE    
Brainstem auditory evoked responses (BAERs) were recorded from 202 patients with definite, probable, or possible multiple sclerosis (MS). Definitions of abnormality were based only on interwave separations and the wave I/wave V amplitude ratio. Thirty-two percent of the patients had abnormal BAERs, and the presence of clinically unsuspected lesions was revealed by BAER abnormalities in 7.4%. Thirty-five percent of the patients who had nystagmus and 53% of those who had internuclear ophthalmoplegia at the time of testing had BAER abnormalities. Forty-five percent of the abnormalities were elicited with stimulation of one ear only, stressing the importance of monaural stimulation. Click rates faster than 10 per second did not reveal abnormalities undetected at slower rates. BAERs were normal by these criteria in patients with labyrinthine diseases and amyotrophic lateral sclerosis. Thus, the BAER in MS can (1) confirm the presence of central lesions in patients with suspected brainstem involvement, (2) document the presence of clinically unsuspected lesions, and (3) be followed over time to provide possible assistance in evaluating the effectiveness of therapeutic measures. The BAER is a useful tool in the diagnosis and management of MS.
K H Chiappa; J L Harrison; E B Brooks; R R Young
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  7     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  IM    
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MeSH Terms
Acoustic Stimulation / methods
Auditory Pathways / physiopathology*
Brain Stem / physiopathology
Diagnosis, Differential
Diplopia / complications
Evoked Potentials
Evoked Potentials, Auditory
Median Nerve / physiopathology
Multiple Sclerosis / complications,  diagnosis*,  physiopathology
Nystagmus, Pathologic / complications
Ophthalmoplegia / complications
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