| Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs. | |
| | |
MedLine Citation:
|
PMID: 8864768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of anti-epileptic drugs (AEDs) on brainstem auditory evoked potentials (BAEPs) were studied on 32 female patients of epilepsy and 10 age-matched normal healthy females (NS). The patients were divided into 6 groups, those not receiving medication (drug free, DF) and those receiving AEDs: Phenytoin (PHT), Carbamazepine (CBZ), Phenobarbital (PB), a combination of PHT and PB and a combination of CBZ and PB. DF epileptics had shortened were V absolute latency (AL) and I-V interpeak latency (IPL) as compared to NS. Phenytoin and CBZ monotherapy produced a prolongation of wave III AL (by PHT only), wave V AL, wave I-III IPL and I-V IPL, as compared to DF epileptics. Phenytoin monotherapy also prolonged wave III AL and I-III IPL, as compared to NS. When PB in the dosage of 30-60 mg/d was used in combination with PHT the above mentioned changes were not observed. These findings indicate altered neuronal conduction and/or synaptic transmission in epileptics. Anti-epileptic drugs in the dosages studied, with exception of PHT appear to lead towards "normalization" of BAEPs. |
| | |
Authors:
|
U Panjwani; S H Singh; W sel Vamurthy; H L Gupta; S Mukhopadhyay; L Thakur |
Related Documents
:
|
150228 - Drug therapy reviews: drug therapy of status epilepticus. 17571348 - Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal ... 16238708 - Issues when treating epilepsy in the elderly. 17295638 - Brain-type natriuretic peptide release and seizure activity during vagal nerve stimulat... 8386368 - Isolation of genetic suppressor elements, inducing resistance to topoisomerase ii-inter... 18982518 - Triple therapy-based targeted nanoparticles for the treatment of helicobacter pylori. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Indian journal of physiology and pharmacology Volume: 40 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 1996 Jan |
Date Detail:
|
Created Date: 1997-02-05 Completed Date: 1997-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: INDIA |
Other Details:
|
Languages: eng Pagination: 29-34 Citation Subset: IM |
Affiliation:
|
Defence Institute of Physiology and Allied Sciences, Timarpur, Delhi. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation Adolescent Adult Anticonvulsants / therapeutic use* Carbamazepine / therapeutic use Drug Combinations Epilepsy / drug therapy*, physiopathology* Evoked Potentials, Auditory, Brain Stem / drug effects* Female Functional Laterality / physiology Humans Phenobarbital / therapeutic use Phenytoin / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 0/Drug Combinations; 298-46-4/Carbamazepine; 50-06-6/Phenobarbital; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Response of the portal vein of spontaneous hypertensive rats to intracellular pH.
Next Document: Effect of noise stress on some cardiovascular parameters and audiovisual reaction time.