Document Detail

Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in piglets.
MedLine Citation:
PMID:  18043517     Owner:  NLM     Status:  MEDLINE    
The ventilatory response to hypoxia is influenced by the balance between inhibitory (GABA, glycine, and taurine) and excitatory (glutamate and aspartate) brainstem amino acid (AA) neurotransmitters. To assess the effects of AA in the nucleus tractus solitarius (NTS) on the ventilatory response to hypoxia at 1 and 2 wk of age, inhibitory and excitatory AA were sampled by microdialysis in unanesthetized and chronically instrumented piglets. Microdialysis samples from the NTS area were collected at 5-min intervals and minute ventilation (VE), arterial blood pressure (ABP), and arterial blood gases (ABG) were measured while the animals were in quiet sleep. A biphasic ventilatory response to hypoxia was observed in wk 1 and 2, but the decrease in VE at 10 and 15 min was more marked in wk 1. This was associated with an increase in inhibitory AA during hypoxia in wk 1. Excitatory AA levels were elevated during hypoxia in wk 1 and 2. Changes in ABP, pH, and ABG during hypoxia were not different between weeks. These data suggest that the larger depression in the ventilatory response to hypoxia observed in younger piglets is mediated by predominance of the inhibitory AA neurotransmitters, GABA, glycine, and taurine, in the NTS.
Dorothy A Hehre; Carlos J Devia; Eduardo Bancalari; Cleide Suguihara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  63     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Department of Pediatrics, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.
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MeSH Terms
Acid-Base Equilibrium
Amino Acids / metabolism*
Animals, Newborn
Anoxia / metabolism*,  physiopathology
Aspartic Acid / metabolism
Blood Pressure
Carbon Dioxide / blood
Disease Models, Animal
Glutamic Acid / metabolism
Glycine / metabolism
Heart Rate
Neurotransmitter Agents / metabolism*
Oxygen / blood
Pulmonary Ventilation*
Respiratory Center / metabolism*,  physiopathology
Respiratory Mechanics
Solitary Nucleus / metabolism*,  physiopathology
Taurine / metabolism
Tidal Volume
Time Factors
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Neurotransmitter Agents; 107-35-7/Taurine; 124-38-9/Carbon Dioxide; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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