| Brainstem Nutrient Sensing in the Nucleus of the Solitary Tract Inhibits Feeding. | |
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MedLine Citation:
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PMID: 23123165 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Direct detection of circulating nutrients by the central nervous system has been implicated in the regulation of energy balance, and the mediobasal hypothalamus is considered as the primary sensing site mediating these effects. Neurons sensitive to energy-related signals have also been identified outside the hypothalamus, particularly within the caudomedial nucleus of the solitary tract (cmNTS) in brainstem, but the consequences of direct cmNTS nutrient detection on energy balance remain poorly characterized. Here we determined the behavioral and metabolic consequences of direct L-leucine detection by the cmNTS and investigated the intracellular signaling and neurochemical pathways implicated in cmNTS L-leucine sensing in rats. Our results support the distributed nature of central nutrient detection, evidence a role for the cmNTS S6K1 pathway in the regulation of meal size and body weight, and suggest that the cmNTS integrates direct cmNTS nutrient detection with gut-derived, descending forebrain, and adiposity signals of energy availability to regulate food intake. |
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Authors:
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Clemence Blouet; Gary J Schwartz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-30 |
Journal Detail:
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Title: Cell metabolism Volume: - ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-11-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Departments of Medicine and Neuroscience, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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