Document Detail


Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding.
MedLine Citation:
PMID:  23123165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Direct detection of circulating nutrients by the central nervous system has been implicated in the regulation of energy balance, and the mediobasal hypothalamus is considered as the primary sensing site mediating these effects. Neurons sensitive to energyrelated signals have also been identified outside the hypothalamus, particularly within the caudomedial nucleus of the solitary tract (cmNTS) in brainstem, but the consequences of direct cmNTS nutrient detection on energy balance remain poorly characterized. Here we determined the behavioral and metabolic consequences of direct L-leucine detection by the cmNTS and investigated the intracellular signaling and neurochemical pathways implicated in cmNTS L-leucine sensing in rats. Our results support the distributed nature of central nutrient detection, evidence a role for the cmNTS S6K1 pathway in the regulation of meal size and body weight, and suggest that the cmNTS integrates direct cmNTS nutrient detection with gut-derived, descending forebrain, and adiposity signals of energy availability to regulate food intake.
Authors:
Clemence Blouet; Gary J Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell metabolism     Volume:  16     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-04-22     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-87     Citation Subset:  IM    
Affiliation:
Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Eating / drug effects*
Energy Metabolism
Hypothalamus / metabolism
Leucine / pharmacology*
Mitogen-Activated Protein Kinase 1 / metabolism
Mitogen-Activated Protein Kinase 3 / metabolism
Rats
Ribosomal Protein S6 Kinases / metabolism
Signal Transduction / drug effects
Solitary Nucleus / enzymology,  metabolism*
Grant Support
ID/Acronym/Agency:
1K99DK093724-01/DK/NIDDK NIH HHS; DK020541/DK/NIDDK NIH HHS; DK026687/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
61-90-5/Leucine; EC 2.7.11.1/Ribosomal Protein S6 Kinases; EC 2.7.11.1/S6K1 protein, rat; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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