Document Detail


Brain volumes in adult survivors of very low birth weight: a sibling-controlled study.
MedLine Citation:
PMID:  15286218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To establish whether adults who were born very low birth weight (VLBW) show altered volumes of certain brain structures. METHODS: Unmatched case-control study was conducted of 33 individuals from a cohort of VLBW (<1500 g) infants who were born between 1966 and 1977 and 18 of their normal birth weight siblings. Whole brain, gray matter, ventricular, corpus callosum, and hippocampal volumes were measured on structural magnetic resonance imaging scans. RESULTS: VLBW individuals had a 46% increase in total ventricular volume and a 17% reduction in posterior corpus callosum volume. No differences in whole brain, gray matter, or hippocampal volumes were observed. CONCLUSION: Specific differences exist in the volumes of certain brain structures in adults who were born VLBW compared with their normal birth weight siblings.
Authors:
Paul Fearon; Paul O'Connell; Sophia Frangou; Peter Aquino; Chiara Nosarti; Matthew Allin; Mark Taylor; Ann Stewart; Larry Rifkin; Robin Murray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  114     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-02     Completed Date:  2004-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-71     Citation Subset:  AIM; IM    
Affiliation:
Section of General Psychiatry, Division of Psychological Medicine, Box 63, Institute of Psychiatry, London SE5 8AF, United Kingdom. p.fearon@iop.kcl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / anatomy & histology*
Case-Control Studies
Cerebral Ventricles / anatomy & histology*
Corpus Callosum / anatomy & histology*
Female
Follow-Up Studies
Humans
Infant, Newborn
Infant, Very Low Birth Weight*
Magnetic Resonance Imaging
Male
Multivariate Analysis
Organ Size
Siblings

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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