Document Detail


Brain volume and shape in infants with deformational plagiocephaly.
MedLine Citation:
PMID:  22447491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Infants with deformational plagiocephaly (DP) have been shown to exhibit developmental delays relative to unaffected infants. Although the mechanisms accounting for these delays are unknown, one hypothesis focuses on underlying differences in brain development. In this study, we used MRI to examine brain volume and shape in infants with and without DP.
METHODS: Participants included 20 infants with DP (mean age = 7.9 months, SD = 1.2; n = 12 male) and 21 controls (mean age = 7.9 months, SD = 1.3; n = 11 male). Measures included volumes of the total brain and cerebellum; midsagittal areas of the corpus callosum and cerebellar vermis; and linear distance measures used to quantify the shape of selected brain structures. We also evaluated the association between shape measures and developmental scores on the Bayley Scales of Infant and Toddler Development-III (BSID-III).
RESULTS: Brain volume did not distinguish cases and controls (p = .214-.976). However, cases exhibited greater asymmetry and flattening of the posterior brain (p < .001-.002) and cerebellar vermis (p = .035), shortening of the corpus callosum (p = .012), and differences in the orientation of the corpus callosum (p = .005). Asymmetry and flattening of brain structures were associated with worse developmental outcomes on the BSID-III.
CONCLUSIONS: Infants with DP show differences in brain shape, consistent with the skull deformity characteristic of this condition, and shape measures were associated with infant development. Longitudinal studies, beginning in the neonatal period, are needed to clarify whether developmental effects precede or follow brain deformation.
Authors:
Brent R Collett; Elizabeth H Aylward; Jessica Berg; Candice Davidoff; Justin Norden; Michael L Cunningham; Matthew L Speltz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-25
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  28     ISSN:  1433-0350     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-10-30     Revised Date:  2014-06-16    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1083-90     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Brain / growth & development*,  pathology*
Developmental Disabilities / pathology*
Female
Humans
Image Processing, Computer-Assisted
Infant
Magnetic Resonance Imaging
Male
Plagiocephaly, Nonsynostotic / pathology*
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
1 R01 HD046565/HD/NICHD NIH HHS; 1 UL1 RR025014/RR/NCRR NIH HHS; R01 HD046565/HD/NICHD NIH HHS; UL1 TR000423/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor.
Next Document:  Homogeneous Human Complex-Type Oligosaccharides in Correctly Folded Intact Glycoproteins: Evaluation...