| Brain volume in autism. | |
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MedLine Citation:
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PMID: 11417608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased brain size has been observed in individuals with autism with a wide range of cognitive functioning. The purpose of this investigation was to obtain measurements of the brain volume in a sample of nonmentally retarded autistic individuals. Magnetic resonance imaging scans from 16 nonmentally retarded individuals with autism and 19 male volunteer comparison subjects were obtained and the following structures were measured: third, fourth, and lateral ventricles and intracranial and cerebral volumes. Mean cerebral and third ventricle volumes in the autistic subjects were significantly greater than in the controls when adjusted for intracranial volume. No other significant results were found. Our finding of increased brain volume in autism is consistent with previous reports in the literature. Additional longitudinal neuroimaging and, more importantly, neuropathologic studies are warranted to provide a better understanding of the complexities underlying increased brain size in autism. |
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Authors:
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A Y Hardan; N J Minshew; M Mallikarjuhn; M S Keshavan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of child neurology Volume: 16 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-21 Completed Date: 2001-12-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 421-4 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA. hardanay@msx.upmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Autistic Disorder / diagnosis* Brain / pathology* Cephalometry Cerebral Ventricles / pathology Child Humans Image Processing, Computer-Assisted* Magnetic Resonance Imaging* Male Observer Variation Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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HD 35469/HD/NICHD NIH HHS; NS 33355/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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