| Brain uptake of glucose in diabetes mellitus: the role of glucose transporters. | |
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MedLine Citation:
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PMID: 2000888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is not known if the diabetes-related reduction in blood-brain barrier (BBB) transport of glucose is due to a change in the functional capacity of transporters or to an as yet unidentified mechanism occurring at the plasma membrane or cytoplasm. To increase our understanding of this problem, the cerebral blood flow, the brain uptake index (BUI) of 3-O-methyl glucose and the concentration of 3H-cytochalasin B binding sites were determined in diabetic rats and diabetic rats treated with insulin. The BUI of 3-O-methyl glucose was significantly reduced (less than 0.001) in diabetic rats (32.7 +/- 1.2%) compared to control rats (41.9 +/- 1.0%). This change could not be attributed to an alteration in cerebral blood flow or to a non-specific change in BBB permeability. Normalization of blood glucose with insulin therapy corrected the BUI measurements in diabetic rats (42.2 +/- 1.4%). The level of measurable glucose transporters measured with 3H-cytochalasin B binding assay did not appear to be reduced in the diabetic brain microvessels. The data indicate that the reduced brain uptake of glucose in chronic hyperglycemia can occur in the absence of a change in glucose transporter concentration. |
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Authors:
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A D Mooradian; A M Morin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 301 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-04-09 Completed Date: 1991-04-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 173-7 Citation Subset: AIM; IM |
Affiliation:
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Tucson VA Medical Center, Arizona. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier* Cytochalasin B / metabolism Diabetes Mellitus, Experimental / metabolism* Glucose / pharmacokinetics* Male Monosaccharide Transport Proteins / physiology* Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Monosaccharide Transport Proteins; 14930-96-2/Cytochalasin B; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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