Document Detail


Brain tumors.
MedLine Citation:
PMID:  23026359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting prognosis and differentiating cerebral lymphoma from nonmalignant lesions. Amino acid tracers including (11)C-methionine, (18)F-fluoroethyltyrosine, and (18)F-L-3,4-dihydroxyphenylalanine provide high sensitivity, which is most useful for detecting recurrent or residual gliomas, including most low-grade gliomas. They also play an increasing role for planning and monitoring of therapy. (18)F-fluorothymidine can only be used in tumors with absent or broken blood-brain barrier and has potential for tumor grading and monitoring of therapy. Ligands for somatostatin receptors are of particular interest in pituitary adenomas and meningiomas. Tracers to image neovascularization, hypoxia, and phospholipid synthesis are under investigation for potential clinical use. All methods provide the maximum of information when used with image registration and fusion display with contrast-enhanced magnetic resonance imaging scans. Integration of PET and magnetic resonance imaging with stereotactic neuronavigation systems allows the targeting of stereotactic biopsies to obtain a more accurate histologic diagnosis and better planning of conformal and stereotactic radiotherapy.
Authors:
Karl Herholz; Karl-Josef Langen; Christiaan Schiepers; James M Mountz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in nuclear medicine     Volume:  42     ISSN:  1558-4623     ISO Abbreviation:  Semin Nucl Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-04-04     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  1264464     Medline TA:  Semin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Neoplasms* / complications,  diagnosis,  pathology,  therapy
Humans
Nuclear Medicine
Opportunistic Infections
Radiopharmaceuticals / diagnostic use
Treatment Outcome
Grant Support
ID/Acronym/Agency:
U01 CA140230/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals
Comments/Corrections

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