| Brain tumor perfusion: comparison of dynamic contrast enhanced magnetic resonance imaging using T1, T2, and T2* contrast, pulsed arterial spin labeling, and H2(15)O positron emission tomography. | |
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MedLine Citation:
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PMID: 18359598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Different techniques for measuring of perfusion are clinically available, but these are usually applied to healthy brain tissue. MATERIAL AND METHODS: Five different techniques were used here in 12 patients with brain tumors to investigate the impact of tumor vascularization on the perfusion signal: three qualitative dynamic contrast-enhanced/susceptibility-contrast magnetic resonance imaging (DCE-MRI/DSC-MRI) techniques exploiting T(1), T(2), T(2)(*) contrast, and two quantitative techniques, pulsed arterial spin labeling (PASL) and H(2)(15)O positron emission tomography (H(2)(15)O-PET). RESULTS: In a first approximation, a linear correlation was found between all five imaging modalities regarding the perfusion signal of both, normal brain tissue and tumor. The estimated values for tumor perfusion differed significantly between the techniques (1=methodical mean in arbitrary units): PASL: 0.83, H(2)(15)O-PET: 0.62, T(1)-DCE: 1.73, T(2)-DCE: 0.69, T(2)(*)-DSC: 0.89. CONCLUSIONS: The tumor perfusion values, determined with different techniques are not comparable. The T(2)(*)-DSC, here applied with contrast agent presaturation of extravascular space, and PASL depict median perfusion most reliably. |
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Authors:
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Lutz Lüdemann; Carsten Warmuth; Michail Plotkin; Annette Förschler; Matthias Gutberlet; Peter Wust; Holger Amthauer |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2008-03-24 |
Journal Detail:
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Title: European journal of radiology Volume: 70 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-15 Completed Date: 2009-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 465-74 Citation Subset: IM |
Affiliation:
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Department of Radiation Medicine, Universitätsklinikum Charité, Campus Virchow-Klinikum, Berlin, Germany. lutz.luedemann@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Brain Neoplasms / blood supply, diagnosis* Contrast Media Gadolinium DTPA / diagnostic use* Glioma / blood supply, diagnosis* Humans Male Middle Aged Neovascularization, Pathologic / diagnosis* Oxygen Isotopes / diagnostic use* Perfusion Imaging / methods* Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Spin Labels Water / diagnostic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Oxygen Isotopes; 0/Radiopharmaceuticals; 0/Spin Labels; 7732-18-5/Water; 80529-93-7/Gadolinium DTPA |
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