Document Detail


Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine.
MedLine Citation:
PMID:  8217497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using positron emission tomography and radio-high performance liquid chromatography, the accumulation of 2'-deoxy-5-18F-fluorouridine in the brain tumors and plasma pharmacokinetic parameters were investigated in 20 patients. High accumulation of the tracer in high grade gliomas and meningiomas and very rapid degradation of the tracer in the plasma were found. Very large variations were observed in both tumor accumulation and pharmacokinetic data. The tumor accumulation, however, did not correlate with any of the plasma pharmacokinetic parameters: area under the plasma concentration-time curve, mean residence time, total body clearance and steady-state volume of distribution. The results suggest that the accumulation of the tracer reflects the metabolic activity of the brain tumor tissues and that the effect of the rapid metabolic change in the tracer in the plasma on the tumor accumulation may be minor.
Authors:
K Ishiwata; Y Tsurumi; M Kameyama; K Sato; R Iwata; T Takahashi; T Ido; T Yoshimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  7     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-03     Completed Date:  1993-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
Affiliation:
Division of Radiopharmaceutical Chemistry, Tohoku University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Neoplasms / metabolism*,  radionuclide imaging
Child
Chromatography, High Pressure Liquid
Female
Floxuridine / blood*,  pharmacokinetics*
Glioma / metabolism*,  radionuclide imaging
Humans
Male
Meningioma / metabolism*,  radionuclide imaging
Middle Aged
Tomography, Emission-Computed
Chemical
Reg. No./Substance:
50-91-9/Floxuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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