| Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine. | |
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MedLine Citation:
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PMID: 8217497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using positron emission tomography and radio-high performance liquid chromatography, the accumulation of 2'-deoxy-5-18F-fluorouridine in the brain tumors and plasma pharmacokinetic parameters were investigated in 20 patients. High accumulation of the tracer in high grade gliomas and meningiomas and very rapid degradation of the tracer in the plasma were found. Very large variations were observed in both tumor accumulation and pharmacokinetic data. The tumor accumulation, however, did not correlate with any of the plasma pharmacokinetic parameters: area under the plasma concentration-time curve, mean residence time, total body clearance and steady-state volume of distribution. The results suggest that the accumulation of the tracer reflects the metabolic activity of the brain tumor tissues and that the effect of the rapid metabolic change in the tracer in the plasma on the tumor accumulation may be minor. |
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Authors:
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K Ishiwata; Y Tsurumi; M Kameyama; K Sato; R Iwata; T Takahashi; T Ido; T Yoshimoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 7 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-12-03 Completed Date: 1993-12-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 199-205 Citation Subset: IM |
Affiliation:
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Division of Radiopharmaceutical Chemistry, Tohoku University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain Neoplasms / metabolism*, radionuclide imaging Child Chromatography, High Pressure Liquid Female Floxuridine / blood*, pharmacokinetics* Glioma / metabolism*, radionuclide imaging Humans Male Meningioma / metabolism*, radionuclide imaging Middle Aged Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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50-91-9/Floxuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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