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Brain tissue volumes in preterm infants: prematurity, perinatal risk factors and neurodevelopmental outcome-A systematic review.
MedLine Citation:
PMID:  22348253     Owner:  NLM     Status:  Publisher    
Abstract Objective: To evaluate the clinical value of neonatal brain tissue segmentation in preterm infants according to the literature. Methods: A structured literature search was undertaken in MEDLINE/Pubmed. This included all publications on volumetric brain tissue assessment in preterm infants at term-equivalent age (TEA) compared to brain tissue volumes of term-born infants, related to perinatal risk factors or related to neurodevelopmental outcome. Results: Sixteen prospective cohort studies, described in 30 articles, fulfilled the criteria. Preterm infants displayed total and regional brain tissue alterations compared to healthy, term-born controls. These alterations seemed more prominent with decreasing gestational age. White matter injury, intraventricular haemorrhage, postnatal corticosteroid therapy, intra-uterine growth retardation and chronic lung disease were frequently associated with volume changes. Associations between volume alterations at TEA and neurodevelopmental outcome in early childhood were shown in only a few studies. Conclusions: Preterm birth is associated with brain tissue volume alterations that become more pronounced in the presence of perinatal risk factors and white matter injury. Moreover, associations between altered volumetric anatomic substrates as early as TEA with long-term neurodevelopmental impairments are scarce.
K Keunen; Kj Kersbergen; F Groenendaal; I Isgum; Ls de Vries; Mjnl Benders
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-21
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neonatology, University Medical Center Utrecht, the Netherlands.
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