| Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. | |
| | |
MedLine Citation:
|
PMID: 20958095 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Intranasal drug delivery is known to overcome the blood-brain barrier (BBB) for delivery of drugs to brain. The objective of this study was to prepare risperidone (RSP)-loaded solid lipid nanoparticles (RSLNs) and explore the possibility of brain targeting by nose-to-brain delivery. RSLNs were prepared by solvent emulsification-solvent evaporation method and characterized for drug content, particle size and size distribution, zeta potential, and in vitro drug-release study. The pharmacodynamic study of RSLNs, which was performed by paw test using Perspex platform, showed higher hindlimb retraction time (HRT) values as compared with RSP solution (RS) indicating the superiority of RSLNs over the RS for brain targeting. The pharmacokinetics and biodistribution studies in mice showed that brain/blood ratio 1 h post-administration of RSLNs (i.n.) was found to be 1.36 ± 0.06 (nearly 10- and 5-fold higher) as compared with 0.17 ± 0.05 for RS (i.v.) and 0.78 ± 0.07 for RSLNs (i.v.), respectively. Gamma scintigraphy imaging of mice brain following intravenous and intranasal administration confirmed the localization of drug in brain. This finding substantiates the existence of direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity. |
| | |
Authors:
|
Sonal Patel; Sandip Chavhan; Heena Soni; A K Babbar; Rashi Mathur; A K Mishra; Krutika Sawant |
Related Documents
:
|
16361085 - Pet neuroimaging of [11c]mirtazapine enantiomers in pigs. 15638085 - Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvess... 868535 - Changes in pharmacodynamics and pharmacokinetics of psycholeptic drugs in the course of... 15811495 - Developmental consequences of antenatal dexamethasone treatment in nonhuman primates. 8923715 - Treatment of acute superficial digital flexor tendon injury in horses with polysulphate... 18160715 - Deubiquitylating enzyme ubp64 controls cell fate through stabilization of the transcrip... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-19 |
Journal Detail:
|
Title: Journal of drug targeting Volume: 19 ISSN: 1029-2330 ISO Abbreviation: J Drug Target Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-06-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9312476 Medline TA: J Drug Target Country: England |
Other Details:
|
Languages: eng Pagination: 468-74 Citation Subset: IM |
Affiliation:
|
Drug Delivery Laboratory, Centre of Relevance and Excellence in NDDS, G.H. Patel Building of Pharmacy, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Type 2 diabetes in the First Nations population: a case example of clinical practice guidelines.
Next Document: Nitrate and nitrite content of human, formula, bovine, and soy milks: implications for dietary nitri...