| Brain structure and obesity. | |
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MedLine Citation:
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PMID: 19662657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is associated with increased risk for cardiovascular health problems including diabetes, hypertension, and stroke. These cardiovascular afflictions increase risk for cognitive decline and dementia, but it is unknown whether these factors, specifically obesity and Type II diabetes, are associated with specific patterns of brain atrophy. We used tensor-based morphometry (TBM) to examine gray matter (GM) and white matter (WM) volume differences in 94 elderly subjects who remained cognitively normal for at least 5 years after their scan. Bivariate analyses with corrections for multiple comparisons strongly linked body mass index (BMI), fasting plasma insulin (FPI) levels, and Type II Diabetes Mellitus (DM2) with atrophy in frontal, temporal, and subcortical brain regions. A multiple regression model, also correcting for multiple comparisons, revealed that BMI was still negatively correlated with brain atrophy (FDR <5%), while DM2 and FPI were no longer associated with any volume differences. In an Analysis of Covariance (ANCOVA) model controlling for age, gender, and race, obese subjects with a high BMI (BMI > 30) showed atrophy in the frontal lobes, anterior cingulate gyrus, hippocampus, and thalamus compared with individuals with a normal BMI (18.5-25). Overweight subjects (BMI: 25-30) had atrophy in the basal ganglia and corona radiata of the WM. Overall brain volume did not differ between overweight and obese persons. Higher BMI was associated with lower brain volumes in overweight and obese elderly subjects. Obesity is therefore associated with detectable brain volume deficits in cognitively normal elderly subjects. |
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Authors:
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Cyrus A Raji; April J Ho; Neelroop N Parikshak; James T Becker; Oscar L Lopez; Lewis H Kuller; Xue Hua; Alex D Leow; Arthur W Toga; Paul M Thompson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human brain mapping Volume: 31 ISSN: 1097-0193 ISO Abbreviation: Hum Brain Mapp Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-05-06 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9419065 Medline TA: Hum Brain Mapp Country: United States |
Other Details:
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Languages: eng Pagination: 353-64 Citation Subset: IM |
Copyright Information:
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2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Pathology, University of Pittsburgh, Pennsylvania, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Analysis of Variance Body Mass Index Brain / pathology* Continental Population Groups Diabetes Mellitus, Type 2 / blood, pathology Fasting / blood Female Humans Insulin / blood Magnetic Resonance Imaging Male Nerve Fibers, Myelinated / pathology Nerve Fibers, Unmyelinated / pathology Obesity / blood, pathology* Organ Size Regression Analysis Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG 20098/AG/NIA NIH HHS; AG016570/AG/NIA NIH HHS; AG05133/AG/NIA NIH HHS; AG15928/AG/NIA NIH HHS; EB01651/EB/NIBIB NIH HHS; P50 AG005133-26/AG/NIA NIH HHS; P50 AG016570-100004/AG/NIA NIH HHS; R01 AG020098-01/AG/NIA NIH HHS; R01 AG020098-02/AG/NIA NIH HHS; R01 AG020098-03/AG/NIA NIH HHS; R01 AG020098-04/AG/NIA NIH HHS; R01 AG020098-05/AG/NIA NIH HHS; R01 AG020098-06A2/AG/NIA NIH HHS; R01 AG020098-07/AG/NIA NIH HHS; R01 AG020098-09/AG/NIA NIH HHS; R21 EB001561-03/EB/NIBIB NIH HHS; R56 AG020098-06A1/AG/NIA NIH HHS; RR019771/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
| Comments/Corrections | |
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