Document Detail

Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm.
MedLine Citation:
PMID:  10335784     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infants born very preterm (<33 weeks) are at increased risk of neurocognitive deficits. Their neurodevelopmental outcome up to age 8 years can be predicted by neonatal ultrasonography, but little is known of their later function. We investigated the effect of very preterm birth on brain structure and neurocognitive and behavioural functioning in adolescence.
METHODS: A cohort of 105 infants born before 33 weeks of gestation in 1979-80 had ultrasonographic scans at University College Hospital, London, and were prospectively examined at 1, 4, and 8 years. At age 14-15 years, 72 of those who remained in UK (cases) and 21 age-matched full-term controls underwent brain magnetic resonance imaging (MRI), as well as neurological, cognitive, and behavioural assessment. MRI images were assessed by two neuroradiologists unaware of ultrasonographic findings or case or control status.
FINDINGS: Of the 72 cases, 40 had unequivocally abnormal MRI and 15 had equivocal scans. Of the 21 controls, one had abnormal and five equivocal MRI. Abnormalities of ventricles, corpus callosum, and white matter were especially common in cases. More brain lesions were identified by MRI than by neonatal ultrasonography. The cases had significantly more reading, adjustment, and neurological impairments than controls, but their behaviour was significantly related to MRI abnormality.
INTERPRETATION: Individuals born very preterm show an excess of neurocognitive and behavioural problems in adolescence, and more than half have abnormal MRI brain scans.
A L Stewart; L Rifkin; P N Amess; V Kirkbride; J P Townsend; D H Miller; S W Lewis; D P Kingsley; I F Moseley; O Foster; R M Murray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  353     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1653-7     Citation Subset:  AIM; IM    
Department of Paediatrics, Rayne Institute, University College London Medical School, UK.
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MeSH Terms
Brain / pathology*
Brain Diseases / etiology*
Child Development
Cognition Disorders / etiology*
Developmental Disabilities / etiology
Follow-Up Studies
Infant, Newborn
Infant, Premature*
Magnetic Resonance Imaging
Neuropsychological Tests
Grant Support
491//Multiple Sclerosis Society

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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