| Brain structure and cerebrovascular risk in cognitively impaired patients: Shanghai Community Brain Health Initiative-pilot phase. | |
| | |
MedLine Citation:
|
PMID: 20937951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the associations among brain morphologic changes as seen on magnetic resonance imaging (MRI), cerebrovascular risk (CVR), and clinical diagnosis and cognition in elderly patients with mild cognitive impairment and dementia living in urban Shanghai. DESIGN: Cross-sectional study performed from May 1, 2007, to November 31, 2008. SETTING: Memory Disorders Clinic of the Huashan Hospital and the Shanghai community. PARTICIPANTS: Ninety-six older people: 32 with normal cognition (NC), 30 with amnestic mild cognitive impairment (aMCI), and 34 with dementia. MAIN OUTCOME MEASURES: For each patient, we administered a neurologic and physical examination, neuropsychological evaluation, and brain MRI and genotyped the apolipoprotein E-ε4 (APOE-ε4) gene. The volumes determined by MRI were assessed using a semiautomatic method. RESULTS: Brain volume was significantly smaller in the dementia patients compared with the NC (P < .001) and aMCI patients (P = .04). Hippocampal volume (HV) was lower and white matter hyperintensity (WMH) volume was higher in those with aMCI (HV: P = .03; WMH volume: P = .04) and dementia (HV: P < .001; WMH volume: P = .002) compared with NC participants. The presence of APOE-ε4 was significantly associated with reduced HV (P = .02). Systolic blood pressure was positively associated with CVR score (P = .04); diastolic blood pressure (P = .02) and CVR score (P = .04) were positively associated with WMH volume. The WMH volume (P = .03) and CVR score (P = .03) were higher among dementia patients compared with NC participants. CONCLUSIONS: Brain structure changes seen on MRI were significantly associated with clinical diagnosis. In addition, blood pressure was highly associated with CVR score and WMH volume. These results suggest that MRI is a valuable measure of brain injury in a Chinese cohort and can serve to assess the effects of various degenerative and cerebrovascular diseases. |
| | |
Authors:
|
Jing He; Ana-Maria Iosif; Dong Young Lee; Oliver Martinez; Shuguang Chu; Owen Carmichael; James A Mortimer; Qianhua Zhao; Ding Ding; Qihao Guo; Douglas Galasko; David P Salmon; Qi Dai; Yougui Wu; Ronald C Petersen; Zhen Hong; Amy R Borenstein; Charles DeCarli |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Archives of neurology Volume: 67 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-12 Completed Date: 2010-10-29 Revised Date: 2012-05-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 1231-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Brain / pathology* Cerebrovascular Disorders / epidemiology*, pathology China Cognition Disorders / diagnosis, epidemiology*, pathology* Cross-Sectional Studies Dementia / epidemiology, pathology Female Humans Logistic Models Magnetic Resonance Imaging / methods Male Middle Aged Neurologic Examination / methods Neuropsychological Tests Odds Ratio Physical Examination Retrospective Studies Risk Factors Urban Population |
| Grant Support | |
ID/Acronym/Agency:
|
K01 AG030514/AG/NIA NIH HHS; K01 AG030514-01A1/AG/NIA NIH HHS; K01 AG030514-04/AG/NIA NIH HHS; P30 AG10129/AG/NIA NIH HHS; R21 AG028182/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Retinopathy and Lobar Intracerebral Hemorrhage: Insights Into Pathogenesis.
Next Document: Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without se...