| Brain-specific protein C activation during carotid artery occlusion in humans. | |
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MedLine Citation:
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PMID: 10066849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Activation of plasma protein C (PC) zymogen by thrombin-thrombomodulin at the endothelial surface is an important endogenous antithrombotic mechanism. It is unknown whether activated protein C (APC) is generated in vivo in the cerebrovasculature, because there is only limited thrombomodulin expression in human brain vascular endothelium. Therefore, we tested the hypothesis that carotid occlusion produces brain-specific PC activation. METHODS: Blood samples were simultaneously collected from the ipsilateral internal jugular vein and radial artery before and during carotid cross-clamping and on "de-occlusion" in 8 awake patients undergoing routine carotid endarterectomy. Plasma PC zymogen and circulating APC levels were measured using enzyme immunocapture assay and expressed as percent of pooled plasma controls. RESULTS: Internal jugular vein APC levels increased 28% exclusively during carotid occlusion and then decreased 32% with de-occlusion (F=8.1, P<0.005). PC zymogen increased only 5.9% with occlusion (F=6.3, P<0.02), consistent with hemoconcentration. There were no changes in radial artery PC or APC levels. CONCLUSIONS: These findings demonstrate brain-specific protein C activation in humans during carotid occlusion and suggest a protective role for endogenous APC generation during cerebrovascular occlusion. |
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Authors:
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R F Macko; L A Killewich; J A Fernández; D K Cox; A Gruber; J H Griffin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 30 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 542-5 Citation Subset: IM |
Affiliation:
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Department of Neurology, Geriatrics Research Education and Clinical Center, Baltimore, Maryland, USA. rmack002@umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Carotid Stenosis / blood* Enzyme Precursors / blood Humans Male Middle Aged Protein C / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P60-AG12583/AG/NIA NIH HHS; R37HL52246/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Precursors; 0/Protein C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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