Document Detail


Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder.
MedLine Citation:
PMID:  17955544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Children and adolescents with maltreatment-related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone-based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co-occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.
Authors:
Steven H Woodward; Danny G Kaloupek; Chris C Streeter; Matthew O Kimble; Allan L Reiss; Stephan Eliez; Lawrence L Wald; Perry F Renshaw; Blaise B Frederick; Barton Lane; Javaid I Sheikh; Wendy K Stegman; Catherine J Kutter; Lorraine P Stewart; Rebecca S Prestel; Ned J Arsenault
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of traumatic stress     Volume:  20     ISSN:  0894-9867     ISO Abbreviation:  J Trauma Stress     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809259     Medline TA:  J Trauma Stress     Country:  United States    
Other Details:
Languages:  eng     Pagination:  763-74     Citation Subset:  IM    
Affiliation:
National Center for PTSD, Clinical Laboratory and Education Division and Psychology Service, VA Palo Alto Healthcare System, Palo Alto, CA 94025, USA. Steve.woodward@med.va.gov
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / physiopathology*
California
Cerebrospinal Fluid / metabolism*
Child
Female
Gulf War
Humans
Magnetic Resonance Imaging
Male
Massachusetts
Skull / physiopathology*
Stress Disorders, Post-Traumatic / physiopathology*
Vietnam Conflict
Grant Support
ID/Acronym/Agency:
K23AA13149/AA/NIAAA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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