Document Detail

Brain single-photon emission CT physics principles.
MedLine Citation:
PMID:  18583408     Owner:  NLM     Status:  MEDLINE    
The basic principles of scintigraphy are reviewed and extended to 3D imaging. Single-photon emission computed tomography (SPECT) is a sensitive and specific 3D technique to monitor in vivo functional processes in both clinical and preclinical studies. SPECT/CT systems are becoming increasingly common and can provide accurately registered anatomic information as well. In general, SPECT is affected by low photon-collection efficiency, but in brain imaging, not all of the large FOV of clinical gamma cameras is needed: The use of fan- and cone-beam collimation trades off the unused FOV for increased sensitivity and resolution. The design of dedicated cameras aims at increased angular coverage and resolution by minimizing the distance from the patient. The corrections needed for quantitative imaging are challenging but can take advantage of the relative spatial uniformity of attenuation and scatter. Preclinical systems can provide submillimeter resolution in small animal brain imaging with workable sensitivity.
R Accorsi
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Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2008-06-26
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  29     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1247-56     Citation Subset:  IM    
Department of Radiology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Equipment Design
Image Processing, Computer-Assisted / instrumentation*
Imaging, Three-Dimensional / instrumentation*
Nuclear Physics
Positron-Emission Tomography / methods
Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon / instrumentation*
Tomography, X-Ray Computed / instrumentation*
Reg. No./Substance:

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