Document Detail

Brain serotonin depletion attenuates diabetogenic effects of streptozotocin.
MedLine Citation:
PMID:  7762635     Owner:  NLM     Status:  MEDLINE    
The diabetogenic effects of streptozotocin (STZ) were studied on blood glucose, plasma insulin, feeding and drinking, body weight, islet morphology, and hypothalamic serotonin (5-HT) release in vehicle-pretreated rats and in rats pretreated with either intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT; a 5-HT nerve fiber depletor), intraperitoneal injection of p-chlorophenylalanine (PCPA; a tryptophan hydroxylase inhibitor), or intraperitoneal injection of p-chloroamphetamine (PCA; a neurotoxin for 5-HT nerve fiber). At four days after STZ administration, vehicle-treated rats displayed hyperglycemia, polydipsia, polyphagia, decreased plasma insulin level, derangement of islet morphology (few insulin cells, accumulation of glucagon cells), and elevated 5-HT release in the hypothalamus. The above diabetogenic effects of STZ were attenuated by brain serotonin depletion induced by 5,7-DHT, PCPA, or PCA. Furthermore, the STZ-induced hyperglycemia or derangement of islet morphology was attenuated by peripheral sympathectomy or adrenalectomy. It is concluded that brain serotonin depletion attenuates diabetogenic effects of STZ by reducing sympathetic efferent activity in rats.
Y F Yang; M T Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E839-44     Citation Subset:  IM    
Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan, Republic of China.
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MeSH Terms
5,7-Dihydroxytryptamine / pharmacology
Brain / metabolism*
Diabetes Mellitus, Experimental / pathology,  physiopathology*
Dopamine / metabolism
Fenclonine / pharmacology
Pancreas / pathology
Rats, Sprague-Dawley
Serotonin / deficiency*,  metabolism
p-Chloroamphetamine / pharmacology
Reg. No./Substance:
31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 64-12-0/p-Chloroamphetamine; 7424-00-2/Fenclonine

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