| Brain serotonin depletion attenuates diabetogenic effects of streptozotocin. | |
| | |
MedLine Citation:
|
PMID: 7762635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The diabetogenic effects of streptozotocin (STZ) were studied on blood glucose, plasma insulin, feeding and drinking, body weight, islet morphology, and hypothalamic serotonin (5-HT) release in vehicle-pretreated rats and in rats pretreated with either intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT; a 5-HT nerve fiber depletor), intraperitoneal injection of p-chlorophenylalanine (PCPA; a tryptophan hydroxylase inhibitor), or intraperitoneal injection of p-chloroamphetamine (PCA; a neurotoxin for 5-HT nerve fiber). At four days after STZ administration, vehicle-treated rats displayed hyperglycemia, polydipsia, polyphagia, decreased plasma insulin level, derangement of islet morphology (few insulin cells, accumulation of glucagon cells), and elevated 5-HT release in the hypothalamus. The above diabetogenic effects of STZ were attenuated by brain serotonin depletion induced by 5,7-DHT, PCPA, or PCA. Furthermore, the STZ-induced hyperglycemia or derangement of islet morphology was attenuated by peripheral sympathectomy or adrenalectomy. It is concluded that brain serotonin depletion attenuates diabetogenic effects of STZ by reducing sympathetic efferent activity in rats. |
| | |
Authors:
|
Y F Yang; M T Lin |
Related Documents
:
|
44325 - Amines and the rat exocrine pancreas: (2) effects of receptor blockers on turnover of l... 14573385 - Acute and chronic effects of corticosterone on 5-ht1a receptor-mediated autoinhibition ... 8263805 - 2'-nh2-mptp in swiss webster mice: evidence for long-term (6-month) depletions in corti... 1723645 - Effects of 5-hydroxytryptophan on extracellular serotonin in the spinal cord of rats wi... 2331565 - Chronic diazepam treatment in rats causes long-lasting changes in central [3h]-5-hydrox... 22781835 - Prolonged hyperoxia preconditioning attenuates behavioral symptoms of 6-hydroxydopamine... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 268 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 May |
Date Detail:
|
Created Date: 1995-06-29 Completed Date: 1995-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: E839-44 Citation Subset: IM |
Affiliation:
|
Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan, Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
5,7-Dihydroxytryptamine
/
pharmacology Animals Brain / metabolism* Diabetes Mellitus, Experimental / pathology, physiopathology* Dopamine / metabolism Fenclonine / pharmacology Male Pancreas / pathology Rats Rats, Sprague-Dawley Serotonin / deficiency*, metabolism p-Chloroamphetamine / pharmacology |
| Chemical | |
Reg. No./Substance:
|
31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 64-12-0/p-Chloroamphetamine; 7424-00-2/Fenclonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of type A endothelin receptors in cultured human myometrial cells.
Next Document: Secretion and clearance of immunoreactive ACTH by fetal lung.