Document Detail


Brain serotonin and the control of food intake in rainbow trout (Oncorhynchus mykiss): effects of changes in plasma glucose levels.
MedLine Citation:
PMID:  12122466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of 5-hydroxytryptamine and its main metabolite 5-hydroxyindoleacetic acid were assessed in two brain regions, hypothalamus and telencephalon, of rainbow trout (Oncorhynchus mykiss) submitted to increases or decreases in plasma glucose levels through different experimental approaches. Thus, intraperitoneal glucose treatment (500 mg kg(-1)) increased 5-hydroxytryptamine telencephalic levels. Long-term food deprivation up to 3 weeks significantly increased hypothalamic (2 weeks and 3 weeks) and telencephalic (1 week, 2 weeks, and 3 weeks) levels of 5-hydroxyindoleacetic acid, whereas the ratio 5-hydroxyindoleacetic acid/5-hydroxytryptamine significantly increased throughout the food-deprivation period assessed. Intraperitoneal treatment with bovine insulin (4 mg kg(-1)) decreased the 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio in hypothalamus after 1 h. Intraperitoneal administration of fenfluramine (3 mg kg(-1)) caused a depression in food intake coincident with a significant decrease of the hypothalamic 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio. These data are discussed in the context of the involvement of serotonergic system in the control of food intake in rainbow trout.
Authors:
C Ruibal; J L Soengas; M Aldegunde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-06-15
Journal Detail:
Title:  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology     Volume:  188     ISSN:  0340-7594     ISO Abbreviation:  J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2003-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101141792     Medline TA:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Affiliation:
Laboratorio de Fisioloxía Animal (Dpto. de Fisioloxía), Facultade de Bioloxía, Universidade de Santiago de Compostela, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Eating / drug effects,  physiology*
Fenfluramine / pharmacology
Glucose / pharmacology
Hydroxyindoleacetic Acid / metabolism
Hypoglycemic Agents / pharmacology
Hypothalamus / metabolism*
Insulin / pharmacology
Oncorhynchus mykiss / metabolism*
Serotonin / metabolism*
Serotonin Agents / pharmacology
Telencephalon / metabolism
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 0/Serotonin Agents; 11061-68-0/Insulin; 458-24-2/Fenfluramine; 50-67-9/Serotonin; 50-99-7/Glucose; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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