Document Detail

Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use.
MedLine Citation:
PMID:  19457377     Owner:  NLM     Status:  MEDLINE    
Manipulations of the serotonin levels in the brain can affect impulsive behavior and influence our reactivity to conditioned reinforcers. Eating, tobacco smoking, and alcohol consumption are reinforcers that are influenced by serotonergic neurotransmission; serotonergic hypofunction leads to increased food and alcohol intake, and conversely, stimulation of the serotonergic system induces weight reduction and decreased food/alcohol intake as well as tobacco smoking. To investigate whether body weight, alcohol intake and tobacco smoking were related to the regulation of the cerebral serotonin 2A receptor (5-HT(2A)) in humans, we tested in 136 healthy human subjects if body mass index (BMI), degree of alcohol consumption and tobacco smoking was associated to the cerebral in vivo 5-HT(2A) receptor binding as measured with (18)F-altanserin PET. The subjects' BMI's ranged from 18.4 to 42.8 (25.2+/-4.3) kg/m(2). Cerebral cortex 5-HT(2A) binding was significantly positively correlated to BMI, whereas no association between cortical 5-HT(2A) receptor binding and alcohol or tobacco use was detected. We suggest that our observation is driven by a lower central 5-HT level in overweight people, leading both to increased food intake and to a compensatory upregulation of cerebral 5-HT(2A) receptor density.
D Erritzoe; V G Frokjaer; S Haugbol; L Marner; C Svarer; K Holst; W F C Baaré; P M Rasmussen; J Madsen; O B Paulson; G M Knudsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-05
Journal Detail:
Title:  NeuroImage     Volume:  46     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-08-19     Revised Date:  2009-09-03    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Alcohol Drinking / genetics,  metabolism*
Body Mass Index*
Brain / metabolism*,  radionuclide imaging
Image Interpretation, Computer-Assisted
Impulsive Behavior / genetics,  metabolism,  radionuclide imaging
Obesity / genetics,  metabolism,  radionuclide imaging
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Positron-Emission Tomography
Promoter Regions, Genetic / genetics
Protein Binding / physiology
Receptor, Serotonin, 5-HT2A / genetics,  metabolism*
Smoking / genetics,  metabolism*
Reg. No./Substance:
0/Receptor, Serotonin, 5-HT2A
Erratum In:
Neuroimage. 2009 Aug 15;47(2):780

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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