Document Detail


Brain responses to food images during the early and late follicular phase of the menstrual cycle in healthy young women: relation to fasting and feeding.
MedLine Citation:
PMID:  21593494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Food intake fluctuates throughout the menstrual cycle; it is greater during the early follicular and luteal phases than in the late follicular (periovulatory) phase. Ovarian steroids can influence brain areas that process food-related information, but the specific contribution of individual hormones and the importance of the prandial state remain unknown.
OBJECTIVE: The objective was to examine whether brain activation during food visualization is affected by changes in estradiol concentration in the fasted and fed conditions.
DESIGN: Nine eumenorrheic, lean young women [mean (±SD) age: 26.2 ± 3.2 y; body mass index (in kg/m(2)): 22.4 ± 1.2] completed 2 visits, one in the early (low estradiol) and one in the late (high estradiol) follicular phase of their menstrual cycle. At each visit, subjects underwent functional magnetic resonance imaging while they viewed food and nonfood images, before and after a standardized meal. Region-of-interest analysis was used to examine the effect of follicular phase and prandial state on brain activation (food > nonfood contrast) and its association with estradiol concentration.
RESULTS: Differences were identified in the inferior frontal and fusiform gyri. In these areas, visualization of food elicited greater activation in the fed state than during fasting but only in the late follicular phase, when estradiol concentration was high. The change in estradiol concentration across the follicular phase (late minus early) was inversely correlated with the change in fusiform gyrus activation in the fasted state but not in the fed state.
CONCLUSION: Our findings suggest that estradiol may reduce food intake by decreasing sensitivity to food cues in the ventral visual pathway under conditions of energy deprivation. This trial was registered at clinicaltrials.gov as NCT00130117.
Authors:
Miguel Alonso-Alonso; Florencia Ziemke; Faidon Magkos; Fernando A Barrios; Mary Brinkoetter; Ingrid Boyd; Anne Rifkin-Graboi; Mary Yannakoulia; Rafael Rojas; Alvaro Pascual-Leone; Christos S Mantzoros
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-18
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  94     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-21     Completed Date:  2011-09-27     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-84     Citation Subset:  AIM; IM    
Affiliation:
Division of Endocrinology, Diabetes and Metabolism, Harvard Medical School, Boston, MA 02215, USA. malonso@bidmc.harvard.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00130117
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiology*
Eating / physiology*
Estradiol / blood,  physiology
Fasting / physiology*
Female
Follicular Phase / physiology*
Humans
Magnetic Resonance Imaging
Visual Perception*
Grant Support
ID/Acronym/Agency:
AG032030/AG/NIA NIH HHS; DK58785/DK/NIDDK NIH HHS; DK79929/DK/NIDDK NIH HHS; DK81913/DK/NIDDK NIH HHS; M01-RR-01032/RR/NCRR NIH HHS; UL1 RR025758/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
50-28-2/Estradiol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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