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Brain proton magnetic spectroscopy in long-term treatment of Wilson's disease patients.
MedLine Citation:
PMID:  21061148     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson's disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated 4 hWD patients, with no improvement and 8 with marked improvement; and 8 nWD patients with marked improvement and 7 with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.
Authors:
Beata Tarnacka; Wojciech Szeszkowski; Marek Gołębiowski; Anna Członkowska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-9
Journal Detail:
Title:  Metabolic brain disease     Volume:  -     ISSN:  1573-7365     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
2nd Neurological Department, Institute of Psychiatry and Neurology, 9 Sobieskiego Str., 02-957, Warsaw, Poland, beatek_ta@poczta.onet.pl.
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