| Brain proton magnetic spectroscopy in long-term treatment of Wilson's disease patients. | |
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MedLine Citation:
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PMID: 21061148 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson's disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated 4 hWD patients, with no improvement and 8 with marked improvement; and 8 nWD patients with marked improvement and 7 with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition. |
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Authors:
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Beata Tarnacka; Wojciech Szeszkowski; Marek Gołębiowski; Anna Członkowska |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-9 |
Journal Detail:
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Title: Metabolic brain disease Volume: - ISSN: 1573-7365 ISO Abbreviation: - Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610370 Medline TA: Metab Brain Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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2nd Neurological Department, Institute of Psychiatry and Neurology, 9 Sobieskiego Str., 02-957, Warsaw, Poland, beatek_ta@poczta.onet.pl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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